Resistance Training Effects on Gut Microbiome and Cardiometabolic Outcomes

Exercise Intervention Clinical Trial

Official title:

Effects of 6-week Resistance Training Intervention on Gut Microbiome and Cardiometabolic Outcomes in Adults With Overweight and Obesity

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04906525
• Other study ID #: 2054484
• Status: Completed
• Phase: N/A
• Start date: May 19, 2021
• Est. completion date: September 30, 2022

Study information

• Verified date: March 2023
• Source: University of Missouri-Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Description:

The overall objective of this study is to investigate the effects of resistance training on the gut microbiome and cardiometabolic outcomes in adults with overweight and obesity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 34
• Est. completion date: September 30, 2022
• Est. primary completion date: September 30, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Age 18-35 years

• BMI: 25-45 kg/m2

• Sedentary lifestyle

• Consistent diet patterns

• Weight-stable (<4 kg change over the last 3 mo)

• Willingness to adhere to resistance training protocol and not change diet

• Non-smoker >1 year or more

Exclusion Criteria:

• Disabilities preventing adherence to resistance training protocol

• Recent start of medications that affect metabolism or appetite

• Antibiotics

• Diabetes

• Drug therapy for coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia

• Uncontrolled hypertension and blood pressure = 180/110

• Gastrointestinal disease and/or bariatric surgery

• Smoking

• Illicit drug use

• Pregnant or lactating individuals

Related Conditions & MeSH terms

• Exercise Intervention

Intervention

Behavioral:
• Resistance training
Participants will undergo 6 weeks of supervised resistance training

Other:
• Conventional physical activity guidelines
Participants are given recommendations on physical activity guidelines

Locations

Country	Name	City	State
United States	University of Missouri	Columbia	Missouri

Sponsors (1)

Lead Sponsor	Collaborator
University of Missouri-Columbia

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Food environment perceptions	subjective and objective questionnaires	baseline and at the end of 6 week intervention
Primary	Change in stool microbiome diversity	16s rRNA sequencing	Change over 6 weeks
Primary	Change in stool microbiome composition	16s rRNA sequencing	Change over 6 weeks
Secondary	Change in blood pressure	diastolic and systolic blood pressure	change over 6 weeks
Secondary	Fat mass	body composition	Change over 6 weeks
Secondary	Fat free mass	body composition	Change over 6 weeks
Secondary	Change in fasting glucose	Fasting Glucose	change over 6 weeks
Secondary	Change in glucose regulation	2 hour glucose clearance	change over 6 weeks
Secondary	Hip circumference	anthropometrics	change over 6 weeks
Secondary	Waist circumference	anthropometrics	change over 6 weeks
Secondary	Physical activity	kcalories burned during free living activity measured by accelerometer	change over 6 weeks
Secondary	Sleep Quality	Measured using actigraphs	change over 6 weeks
Secondary	Sleep Duration	Measured using actigraphs	change over 6 weeks
Secondary	24hr appetite ratings	Subjective rating using visual analog scales	Once at baseline and at the end of 6 week intervention
Secondary	Change in Body mass	Measured in kg	change over 6 weeks
Secondary	Short chain fatty acids	Acetate, propionate, and butyrate	Change over 6 weeks