Exercise Induced Asthma Clinical Trial
— IMT_EIBOfficial title:
Effect of Flow-Resistive Inspiratory Muscle Training on The Severity of Exercise-Induced Bronchoconstriction and Cycling Time-Trial Performance
Due to the lack of studies examining the impact of inspiratory muscle training (IMT) on the severity of exercise-induced bronchoconstriction (EIB) and exercise performance, the specific aim of this study is to assess the efficacy of flow-resistive IMT on EIB severity and symptoms, short-acting beta-2-agonist medication use, operating lung volumes, respiratory and limb locomotor muscle deoxygenation during constant-load cycling exercise, exertional dyspnea, and cycling time-trial performance.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | August 2025 |
Est. primary completion date | August 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 35 Years |
Eligibility | Inclusion Criteria: - Male and female, between the ages of 18 to 35 years. - Required to be a competitive recreational or college athlete and have at least 1-2 years of cycling or biking experience. - Body Mass Index (BMI) of 18.5 to 28 kg/m^2 - Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ). - Have clinically treated mild to moderate persistent asthma and/or exercise-induced bronchoconstriction (EIB), with a resting forced expiratory volume in 1 second (FEV1) > 65% of predicted. - A = 10% drop in FEV1 after eucapnic voluntary hyperpnea (EVH). - Prescribed short-acting ß2-agonists (SABAs) by a physician. - Comfortable not taking SABA before experimental visits. Exclusion Criteria: - History of smoking or recreational smoking, cardiovascular disease, renal disease, neurological disease, and metabolic disease. - Currently taking asthma maintenance medications (e.g., corticosteroids and leukotriene modifiers) - Any injuries in the past 6 months. - Taking selective serotonin reuptake inhibitors (SSRI)'s (antidepressants and anxiety medication), attention-deficit hyperactivity disorder (ADHD) medication, and chronically consume pain medication (Aleve, Tylenol, cannabidiol (CBD), etc.). - Has had or is positive for COVID-19. - Resting blood pressure of > 130 mmHg systolic or 90 mmHg diastolic. - Resting Pulse rate of > 100 bpm. - Regularly consuming fish oil supplements or eating more then one fish meal per week |
Country | Name | City | State |
---|---|---|---|
United States | School of Public Health-Bloomington | Bloomington | Indiana |
Lead Sponsor | Collaborator |
---|---|
Indiana University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Exercise-Induced Bronchoconstriction (EIB) Severity | More specifically, the pre- and post-values of the percentage drop in forced expiratory volume in 1 second (FEV1) from the eucapnic voluntary hyperpnea (EVH) test before and after IMT will be measured. Percentage drop in forced expiratory volume in 1 second (FEV1) will be reported in percentages. | 8 weeks | |
Primary | Maximum Inspiratory Pressure and Sustained Maximum Inspiratory Pressure | More specifically, the pre- to post-values of maximum inspiratory pressure (reported as cmH2O) and sustained maximum inspiratory pressure (reported as pressure time units) before and after IMT will be measured. | 8 weeks | |
Primary | 16-km Cycling Time-Trial Time to Completion | More specifically, differences in 16-km cycling time-trial completion time (seconds) before and after IMT. | 8 weeks | |
Primary | 16-km Cycling Time-Trial Power Output | More specifically, differences in 16-km cycling time-trial power output (watts) before and after IMT. | 8 weeks | |
Primary | Constant Load Performance | More specifically, differences in constant load performance (i.e., power output [watts]) before and after IMT. | 8 weeks | |
Secondary | Perception of Breathing Intensity and Unpleasantness and Leg Fatigue | More specifically, whether IMT affects an individual's perception of exertional dyspnea (revised Borg Scales from 0-10 to rate breathing intensity and unpleasantness) and revised Borg Scales from 0-10 to rate leg fatigue during constant load cycling and a 16-km cycling time-trial. Scores will be reported as whole numbers between 0-10. Higher scores indicate extreme intensity, unpleasantness, or fatigue. | 8 weeks | |
Secondary | Deoxygenation of the respiratory and limb locomotor muscles by near-infrared spectroscopy | More specifically, the effects of IMT on the deoxygenation of the respiratory and limb locomotor muscles during constant load cycling and a 16-km cycling time-trial | 8 weeks | |
Secondary | Femoral blood flow (FBF) of the limb locomotor muscles by ultrasound | More specifically, the effects of IMT on femoral blood flow (FBF) of the limb locomotor muscles during constant load cycling | 8 weeks | |
Secondary | Lung Volumes | More specifically, the effects of IMT on operating lung volumes during constant load cycling and a 16-km cycling time-trial. | 8 weeks |
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