Exercise Challenge in a Cold Chamber

Exercise-induced Asthma Clinical Trial

Official title: Exercise-induced Bronchoconstriction in a Cold Chamber Compared to Methacholine Challenge

Status Completed

Clinical Trial Summary

The purpose of this study is to compare the exercise-challenge in a cold chamber at 2-4°C to the gold standard the metacholine challenge in subjects showing symptoms of exercise-induced bronchoconstriction. The sensitivity and repeatability of the exercise test will be measured.

Clinical Trial Description

Subjects suffering form exercise-induced bronchoconstriction (EIB) usually have a normal lung function testing at rest. To provoke asthma symptoms a provocation test is necessary, e.g., by bronchial methacholine testing or by a standardised exercise test on a treadmill. The correlation between methacholine and exercise test is fair, possibly because both methods measure different kinds of bronchial hyperresponsiveness. Moreover, the sensitivity and the repeatability of the exercise test is fair.

The value of the methacholine test to predict a positive exercise test will be measured. We hypothesize that the exercise test in a cold chamber, a combination of two provocation methods cold air and exercise, is more sensitive to detect EIB and that the test has a better repeatability. ;

Study Design

Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Asthma, Exercise-Induced
• Exercise-induced Asthma

• NCT number: NCT02026492
• Study type: Interventional
• Source: Johann Wolfgang Goethe University Hospitals
• Status: Completed
• Phase: N/A
• Start date: June 2013
• Completion date: July 2014