Different Domains of Executive Function Dual Task Walking on Brain

Status Completed

Clinical Trial Summary

The aim of this study is to investigate the effects of different domains of executive function (EF) during dual task walking condition on brain activation and gait performance in healthy adults. There are two experiments will be conducted in this study. Experiment 1 is a pilot study to determine the same level of difficulty in 3 EF domains, including inhibition, working memory and cognitive flexibility. Experiment 2 is carried out to investigate the effects of 3 different domains of EF which difficulties are controlled on gait performance and brain activation in dual task condition. 10 subjects will perform Stroop test (2s/3s/4s to change question), backward digit spans (3/4/5 digits) and naming test in Experiment 1. In Experiment 1, the primary outcome is the correct response speed (CRS) while secondary outcome will be the brain activity. In Experiment 2, 30 subjects will perform the single cognitive task A (SCTA, Stroop test), single cognitive task B (SCTB, backward digit spans), single cognitive task C (SCTC, naming test), single walking task (SWT), dual task A (DTA, walking while performing cognitive task A), dual task B (DTB, walking while performing cognitive task B) and dual task C (DTC, walking while performing cognitive task C). The CRS, gait performance, brain activity and the dual task costs (DTC) will be recorded in the Experiment 2. Brain activities in prefrontal cortex (PFC), premotor cortex (PMC) and supplementary motor area (SMAs) will be measured by functional near-infrared spectroscopy (fNIRS) during this study. One-way ANOVA with Tukey post-hoc test will be performed to establish the effect of different type of executive task on CRS or the brain activity. The differences of gait parameters and brain activity in different condition in the Experiment 2 will be examined by one-way ANOVA with repeated measured. Furthermore, the Pearson correlation coefficient will be used to examine the correlation of brain activation and executive function performance or gait parameters.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04905186
Study type	Observational
Source	National Taiwan University Hospital
Contact
Status	Completed
Phase
Start date	August 1, 2021
Completion date	May 23, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT06038435` - The Effect of Cognitive Orientation Approach on Daily Occupational Performance With Autism Spectrum Disorder	N/A
Completed	`NCT01365897` - Effectiveness of Modafinil in Improving Cognitive Performance of University Students	Phase 4
Active, not recruiting	`NCT00747396` - The Bucharest Early Intervention Project	N/A
Not yet recruiting	`NCT05513339` - Effect of Sleep Deprivation on Cognitive Function Among Cardiology Fellows
Completed	`NCT03003286` - Community Based Intervention for Children With ADHD and ASD	N/A
Not yet recruiting	`NCT05468216` - Movement Integration in Primary Schools' Lessons	N/A
Not yet recruiting	`NCT03946254` - Effect of Strength Training on Executive Functions in Elderly People With Mild Cognitive Impairment	N/A
Completed	`NCT04082247` - Healthy Children 2021 Study in Childcare Centers	N/A
Completed	`NCT03800030` - Effect of Cross Frequency tACS on Cognitive Control	N/A
Recruiting	`NCT04989712` - MOReS Freestyle Libre Validation Study	N/A
Active, not recruiting	`NCT05290584` - Influence of Preschool Children's Fundamental Movement Skills, Physical Activity, and Physical Fitness on Executive Function: A Prospective Observation Study
Recruiting	`NCT06175897` - Effects of STN DBS on Cognition and Brain Networks in PD Patients Analyzed Based on EEG and fNIRS	N/A
Not yet recruiting	`NCT04103463` - Interactive Stepping Exercise on Memory	N/A
Completed	`NCT03443323` - Organizational Skills Training	N/A
Completed	`NCT04329663` - Effectiveness of the Indonesian Computer-based Game	N/A
Not yet recruiting	`NCT01718405` - Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function	N/A
Recruiting	`NCT06241300` - Executive Function and Parenting in Childhood	N/A
Completed	`NCT05910632` - Eccentrically Reinforced Resistance Training vs. Traditional Resistance Training in Sedentary Older Women	N/A
Completed	`NCT05462977` - Rhythmically Entrained Exercise in Community-Dwelling Older Adults	N/A
Not yet recruiting	`NCT06286943` - The Effects of Short-Chain Fatty Acids in Psychosocial Stress-Induced Impairment on Core Executive Functions	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Different Domains of Executive Function Dual Task Walking on Brain Activation and Gait Performance in Healthy Adults

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms