Clinical Trials Logo

Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT03946254
Other study ID # University of seville
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date September 1, 2019
Est. completion date June 15, 2020

Study information

Verified date May 2019
Source University of Seville
Contact manuel jesus j roldan, Sports Sci
Phone 650344644
Email jimenez.roldan.manueljesus@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Cognitive impairment or dementia is their last degree in one of the main concerns at a social level in these ages. To this day, there are different pharmacological and non-pharmacological therapies that can help prevent deterioration, as in this case, physical exercise.

In the existing scientific literature, you can find a lot of information about the effect of aerobic exercise on cognition, but little is known about the effect of force exercise and its effect on general cognition and executive functions.

Therefore, in this research the investigators will investigate the effect of strength training in people over 60 with a diagnosis of mild cognitive impairment in executive functions. For this, a controlled and randomized clinical trial will be developed in the city of Seville


Description:

The training program will last 20 weeks and a frequency of 3 times / week.

During the week 0 the initial evaluation will be developed. Between weeks 1-20, the training program will be addressed. In week 21, all the changes made in all the measured variables will be evaluated.

Finally, in week 33 the variables will be measured again to see if the possible improvements given in the training program last over time.

The experimental group will perform a planned and individualized training with guided machines and training loads will be adjusted at the beginning of each week.

The control group will perform breathing and relaxation exercises to avoid a sample death.

After the intervention, there will be a follow-up phase for 3 months.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 40
Est. completion date June 15, 2020
Est. primary completion date March 15, 2020
Accepts healthy volunteers No
Gender All
Age group 60 Years and older
Eligibility Inclusion Criteria:

- The sample is made up of people over 60 years of age, who are not active professionally, speak and understand the Spanish language.

- In addition, they should be diagnosed with mild cognitive impairment. This will be evaluated by specialists through the minimental test (score between 24 and 28).

- On the other hand, they should not suffer from other serious psychiatric or neurodegenerative neurological diseases.

- In relation to mental health, it will be a reason for exclusion to have had 3 episodes of depression in the last 5 years or 10 episodes that have required some psychiatric or medical treatment.In addition,

- The people included must be postmenopausal

Exclusion Criteria:

- Participate in other physical exercise programs in a systematic way or in individualized and systematic programs in cognitive programs.

- Dispose of cardiovascular diseases, heart diseases that involve an absolute contradiction of physical exercise (unstable angina, severe auroventricular block) and cerebrovascular or have suffered a heart attack in the last 6 years.

- Have had seizures (More than 2 in the last 12 months).

- Consumption of alcohol 20 grams / day or 2 beers or wine glasses daily.

- Functional limitations (According to Functional activities Questionnaire)

- Being a musician or bilingual.

Study Design


Intervention

Other:
Effect of strength training on executive functions in elderly people with mild cognitive impairment.
Strength training sessions will have a frequency of 3 times per week (Monday, Tuesday and Wednesday) for 20 weeks. In addition, each subject is subject to an individualized training program according to the workload in order to progressively increase the intensity of work. The workload will be modified progressively by influencing both the total volume of repetitions and the intensity of the exercises. The exercises will be controlled movements and not harmful, as guided machines will be used to facilitate the execution of actions. In addition, the largest amount of muscle groups to be able to generate strength gains in all muscle groups. The control group will perform breathing exercises and low intensity stretching during the same days and with the same duration as the experimental group

Locations

Country Name City State
Spain Education Faculty Seville

Sponsors (1)

Lead Sponsor Collaborator
University of Seville

Country where clinical trial is conducted

Spain, 

Outcome

Type Measure Description Time frame Safety issue
Primary Baseline of Inhibitory control To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors.
Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory control.
week 0
Primary Mean Change from Baseline in Inhibitory control To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors.
Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
week 21
Primary Inhibitory control in the follow-up phase To measure the inhibitory control, the "Stroop test" will be used. It is a short test and consists of 3 parts. In the first part they must read the greatest number of words in a sheet with a total of 100 words that appear in 5 columns. For 45 seconds they should read the largest number of words. At the end of the time the number will be written down of words read. Next, they should identify colors from a list of symbols without meaning, but colored in different colors. The subject will have to identify and name the greatest number of colors.
Finally, the subject is given a list of words with the name of colors, but written with a different color from the one the word refers to.This test aims to assess the inhibitory controlof words read.
week 33
Secondary Baseline of general cognition Global cognition is evaluated through the mini-mental test (Folstein, Folstein, & McHugh, 1975). It is a brief and quick test to apply and is frequently used to diagnose the degree of cognitive decline. It should be noted how various variables such as the socio-educational level, and age among others, can affect the result. In addition, the mini-mental test is low cost and can be applied by any professional with a minimum of knowledge and training towards their development. The diagnostic values for mild cognitive impairment are between 24 and 28. Week 0
Secondary Mean Change from Baseline in General cognition Global cognition is evaluated through the mini-mental test (Folstein, Folstein, & McHugh, 1975). It is a brief and quick test to apply and is frequently used to diagnose the degree of cognitive decline. It should be noted how various variables such as the socio-educational level, and age among others, can affect the result. In addition, the mini-mental test is low cost and can be applied by any professional with a minimum of knowledge and training towards their development. The diagnostic values for mild cognitive impairment are between 24 and 28. week 21
Secondary General cognition in the follow-up phase Global cognition is evaluated through the mini-mental test (Folstein, Folstein, & McHugh, 1975). It is a brief and quick test to apply and is frequently used to diagnose the degree of cognitive decline. It should be noted how various variables such as the socio-educational level, and age among others, can affect the result. In addition, the mini-mental test is low cost and can be applied by any professional with a minimum of knowledge and training towards their development. The diagnostic values for mild cognitive impairment are between 24 and 28. week 33
Secondary Baseline of physical condition Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli & Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests: The tests described here are quantified by the distance achieved.
Test of flexibility of the lower extremities, Put your hands behind your back, Get up and walk and sit down again.
In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
week 0
Secondary Mean Change from Baseline in Physical condition Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli & Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests: The tests described here are quantified by the distance achieved.
Test of flexibility of the lower extremities, Put your hands behind your back, Get up and walk and sit down again.
In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
week 21
Secondary Physical condition in the follow-up phase Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli & Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests: The tests described here are quantified by the distance achieved.
Test of flexibility of the lower extremities, Put your hands behind your back, Get up and walk and sit down again.
In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
week 33
Secondary Baseline of physical condition variante Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli & Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests. The tests described here are quantified by the maximum number of repetitions performed.
Sit and get up from a chair for 30 seconds, push-ups for 30 seconds, In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
week 0
Secondary Mean Change from Baseline in Physical condition variante Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli & Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests. The tests described here are quantified by the maximum number of repetitions performed.
Sit and get up from a chair for 30 seconds, push-ups for 30 seconds, In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
week 21
Secondary Physical condition variante in the follow-up phase Senior Fitness Test. This test battery allows us to evaluate the physical condition of elderly people safely. This battery can develop in ages from 60 to 94 years, encompassing various levels of physical and functional capacity (Rikli & Jones, 1999).Due to its easy application, no specific material is required for its development, so it can be developed outside the laboratory.
This test battery consists of 7 tests. The tests described here are quantified by the maximum number of repetitions performed.
Sit and get up from a chair for 30 seconds, push-ups for 30 seconds, In all the tests, the distance or number of repetitions made will be noted to later make comparisons with reference tables already established according to the ages.
week 33
Secondary Baseline of blood test Only 15 ml of blood will be extracted from the antecubital vein to measure the concentrations of different biochemical parameters, such as the BDFN and IGF-1. To avoid interferences in the blood analysis, it is necessary that the patient goes on an empty stomach. It is also necessary that during the previous day the participant fulfills a normal sleep monitoring cycle and that he does not eat chocolate, cocoa, tea, coffee or any other stimulant. week 0
Secondary Mean Change from Baseline in Blood test Only 15 ml of blood will be extracted from the antecubital vein to measure the concentrations of different biochemical parameters, such as the BDFN and IGF-1. To avoid interferences in the blood analysis, it is necessary that the patient goes on an empty stomach. It is also necessary that during the previous day the participant fulfills a normal sleep monitoring cycle and that he does not eat chocolate, cocoa, tea, coffee or any other stimulant. week 21
Secondary Baseline of strength The point of maximum power is an elaborate and accurate assessment of muscle strength and is often evaluated at a speed of 60º per second. Therefore, the Biodex 4 system will be used to assess the capacity to generate the power peak of each subjectby knee extension. week 0
Secondary Mean Change from Baseline in Strength The point of maximum power is an elaborate and accurate assessment of muscle strength and is often evaluated at a speed of 60º per second. Therefore, the Biodex 4 system will be used to assess the capacity to generate the power peak of each subjectby knee extension. week 21
Secondary Strength in the follow-up phase The point of maximum power is an elaborate and accurate assessment of muscle strength and is often evaluated at a speed of 60º per second. Therefore, the Biodex 4 system will be used to assess the capacity to generate the power peak of each subjectby knee extension. week 33
Secondary Baseline of cognitive flexibility To evaluate the cognitive flexibility, will be used the WISCONSIN TEST. This test consists of two sets of 64 cards. The letters present various combinations according to 4 geometric shapes, 4 colors and 4 quantities. week 0
Secondary Mean Change from Baseline in cognitive flexibility To evaluate the cognitive flexibility, will be used the WISCONSIN TEST. This test consists of two sets of 64 cards. The letters present various combinations according to 4 geometric shapes, 4 colors and 4 quantities. week 21
Secondary cognitive flexibility in the follow-up phase To evaluate the cognitive flexibility, will be used the WISCONSIN TEST. This test consists of two sets of 64 cards. The letters present various combinations according to 4 geometric shapes, 4 colors and 4 quantities. week 33
Secondary Baseline of cognitive flexibility variante "Trail Making test part B" will be used to assess cognitive flexibility. This reliable test and valid consists of a page where you must surround numbers and letters. The numbers are they extend from 1 to 13 and the letters from A to L. week 0
Secondary Mean Change from Baseline in cognitive flexibility variante "Trail Making test part B" will be used to assess cognitive flexibility. This reliable test and valid consists of a page where you must surround numbers and letters. The numbers are they extend from 1 to 13 and the letters from A to L. week 21
Secondary cognitive flexibility variante in the follow-up phase "Trail Making test part B" will be used to assess cognitive flexibility. This reliable test and valid consists of a page where you must surround numbers and letters. The numbers are they extend from 1 to 13 and the letters from A to L. week 33
Secondary Baseline of working memory For that, wi will used the Verbal digit span forward and backward tests.This test is an excellent tool to evaluate working memory. The examiner reads a sequence of numbers and the participant must repeat it. It is composed of two parts, direct or indirect. In the first the subject must say the sequence of numbers in the order they appear. On the other hand, the indirect must name the numbers that appeared in reverse order. The length of the sequences of numbers increases progressively and two sequences with the same number are always administered. The task is suspended when the subject fails twice in the same sequence. This test gives us a measure of the attention capacity and working memory. week 0
Secondary Mean Change from Baseline in working memory For that, wi will used the Verbal digit span forward and backward tests.This test is an excellent tool to evaluate working memory. The examiner reads a sequence of numbers and the participant must repeat it. It is composed of two parts, direct or indirect. In the first the subject must say the sequence of numbers in the order they appear. On the other hand, the indirect must name the numbers that appeared in reverse order. The length of the sequences of numbers increases progressively and two sequences with the same number are always administered. The task is suspended when the subject fails twice in the same sequence. This test gives us a measure of the attention capacity and working memory. week 21
Secondary Working memory in the follow-up phase For that, wi will used the Verbal digit span forward and backward tests.This test is an excellent tool to evaluate working memory. The examiner reads a sequence of numbers and the participant must repeat it. It is composed of two parts, direct or indirect. In the first the subject must say the sequence of numbers in the order they appear. On the other hand, the indirect must name the numbers that appeared in reverse order. The length of the sequences of numbers increases progressively and two sequences with the same number are always administered. The task is suspended when the subject fails twice in the same sequence. This test gives us a measure of the attention capacity and working memory. week 33
See also
  Status Clinical Trial Phase
Completed NCT06038435 - The Effect of Cognitive Orientation Approach on Daily Occupational Performance With Autism Spectrum Disorder N/A
Completed NCT01365897 - Effectiveness of Modafinil in Improving Cognitive Performance of University Students Phase 4
Active, not recruiting NCT00747396 - The Bucharest Early Intervention Project N/A
Not yet recruiting NCT05513339 - Effect of Sleep Deprivation on Cognitive Function Among Cardiology Fellows
Completed NCT03003286 - Community Based Intervention for Children With ADHD and ASD N/A
Not yet recruiting NCT05468216 - Movement Integration in Primary Schools' Lessons N/A
Completed NCT04082247 - Healthy Children 2021 Study in Childcare Centers N/A
Completed NCT03800030 - Effect of Cross Frequency tACS on Cognitive Control N/A
Recruiting NCT04989712 - MOReS Freestyle Libre Validation Study N/A
Active, not recruiting NCT05290584 - Influence of Preschool Children's Fundamental Movement Skills, Physical Activity, and Physical Fitness on Executive Function: A Prospective Observation Study
Recruiting NCT06175897 - Effects of STN DBS on Cognition and Brain Networks in PD Patients Analyzed Based on EEG and fNIRS N/A
Not yet recruiting NCT04103463 - Interactive Stepping Exercise on Memory N/A
Completed NCT03443323 - Organizational Skills Training N/A
Completed NCT04329663 - Effectiveness of the Indonesian Computer-based Game N/A
Not yet recruiting NCT01718405 - Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function N/A
Recruiting NCT06241300 - Executive Function and Parenting in Childhood N/A
Completed NCT05910632 - Eccentrically Reinforced Resistance Training vs. Traditional Resistance Training in Sedentary Older Women N/A
Completed NCT05462977 - Rhythmically Entrained Exercise in Community-Dwelling Older Adults N/A
Recruiting NCT06436209 - Cognitive Control & the Functional Organization of the Frontal Cortex N/A
Not yet recruiting NCT06286943 - The Effects of Short-Chain Fatty Acids in Psychosocial Stress-Induced Impairment on Core Executive Functions N/A