Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function

Executive Function Clinical Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT01718405
• Other study ID #: 0049
• Status: Not yet recruiting
• Phase: N/A
• First received: October 10, 2012
• Last updated: October 29, 2012
• Start date: November 2012
• Est. completion date: November 2017

Study information

• Verified date: October 2012
• Source: Hillel Yaffe Medical Center
• Contact: Sharon Tsuk, PhD
• Phone: 972-522-640642
• Email: sharontsuk1[@]gmail.com
• Is FDA regulated: No
• Health authority: Israel: Ministry of Health
• Study type: Interventional

Clinical Trial Summary

Studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise. The main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 150
• Est. completion date: November 2017
• Est. primary completion date: November 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 20 Years to 35 Years

Eligibility

Inclusion Criteria:

• Physical Education Students

• Able to sign consent form

Exclusion Criteria:

• Competitive athletes

• Smokers

• Neurologic or psychologic orders

• Chronic diseases

• Head Injuries

• Hospitalization in the previous 3 months

• Pregnant

Study Design

Intervention Model: Single Group Assignment, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Executive Function

Intervention

Other:
• Cognitive function after exercise test
The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.

Genetic:
• Blood sample analysis
In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.

Locations

Country	Name	City	State
Israel	Wingate Institute	Netanya

Sponsors (1)

Lead Sponsor	Collaborator
Hillel Yaffe Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Genetic Variation Associated with Different Cognitive Functioning	Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.	Two years	No
Primary	Cognitive Functioning After Exercise	Computerized battery of tests evaluating cognitive functioning	Five minutes	No