Pulmonary Disease, Chronic Obstructive Clinical Trial
Official title:
Respiratory Microbiome and COPD Exacerbations
The global objective of this coordinated project is to test the following hypotheses: 1) the
lung microbiome in chronic obstructive pulmonary disease (COPD) is different in patients
suffering from frequent exacerbations (FE) compared those who do not (NE ); 2) The microbial
profile of patients with FE is associated with a different local and systemic inflammatory
pattern; and 3) the inflammatory and immune characteristics of COPD are modulated by the
intestinal microbiome.
The project is based on bronchoalveolar lavage (BAL) for sampling lung microbiome, and
includes analysis of regional variability (intrapulmonary) and temporal variability. The
project will also assess the correlation between BAL samples obtained from the proximal
airway (oral cavity, oropharynx and sputum), and the representation of lung microbiome in
them. A cohort of COPD patients (n = 50 FE; n = 50 NE) and healthy subjects (n= 30), matched
by age, sex and tobacco consumption. Respiratory secretion samples will be collected in
clinical stability samples, with resampling in a quarter of the participants at 6-9 months.
Coordinator Project: Bacterial and fungal microbiota will be determined by 16S rRNA and ITS
amplification and sequencing. Virome and functional metagenomics will be analyzed in a
quarter of the participants. Subprojects: Regional variability in the lung, local and
systemic inflammatory response, and the relationship between the intestinal microbiome and
inflammatory and clinical characteristics of the disease will be determined. The integration
of the results will be performed using network medicine methodologies. The results of this
project will help to understand the pathogenesis of COPD and its exacerbations with the final
aim to identify new therapeutic targets.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
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