End Stage Renal Disease Clinical Trial
Official title:
Comparison of Citrate and Heparin Anticoagulation During Hemodialysis With Medium Cut-off Polyarylethersulphone- Polyvinylpirrolidone (Theranova) Membrane
Verified date | June 2022 |
Source | University Medical Centre Ljubljana |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of the study is to compare the efficiency and biocompatibility of citrate and heparin anticoagulation during hemodialysis with medium cut-off polyarylethersulphone-polyvinylpirrolidone membrane (Theranova®).
Status | Active, not recruiting |
Enrollment | 32 |
Est. completion date | December 2022 |
Est. primary completion date | December 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - patient on chronic hemodialysis - age 18 years old or more - being able to give an informed consent to participate in the survey Exclusion Criteria: - on therapeutic anticoagulation - citrate or heparin contraindicated - citrate or heparin intolerance - acute renal failure |
Country | Name | City | State |
---|---|---|---|
Slovenia | University Medical Centre Ljubljana | Ljubljana |
Lead Sponsor | Collaborator |
---|---|
Marija Malgaj Vrecko |
Slovenia,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clearance of beta-2 microglobulin | Overall and instantaneous clearance of beta-2 microglobulin. | At the end of each hemodialysis procedure. | |
Primary | Clearance of phosphate | Overall and instantaneous clearance of phosphate. | At the end of each hemodialysis procedure. | |
Primary | Serum concentration of C3a, C5a, myeloperoxidase and PF-4 | Blood for the laboratory measurements will be taken from the arterial line. | At the start, after 15 minutes and at the end of each hemodialysis procedure. | |
Secondary | Clearance of urea | Overall and instantaneous clearance of urea. | At the end of each hemodialysis procedure. | |
Secondary | Clearance of creatinine | Overall and instantaneous clearance of creatinine. | At the end of each hemodialysis procedure. | |
Secondary | Clearance of p-cresol | Overall and instantaneous clearance of p-cresol. | At the end of each hemodialysis procedure. | |
Secondary | White blood cell count | Blood for the laboratory measurements will be taken from the arterial line. | At the start, after 15 minutes and at the end of each hemodialysis procedure. | |
Secondary | Blood platelet count | Blood for the laboratory measurements will be taken from the arterial line. | At the start, after 15 minutes and at the end of each hemodialysis procedure. |
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