Renal Anemia Refractory to Erythropoietin

ESRD Clinical Trial

Official title:

Renal Anemia Refractory to Erythropoietin

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03480178
• Other study ID #: 17100366
• Status: Not yet recruiting
• Start date: January 2019
• Est. completion date: May 2019

Study information

• Verified date: December 2018
• Source: Assiut University
• Contact: zaher alwi, master
• Phone: 01020361266
• Email: binalwi2009[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study evaluates the renal anemia refractory to Epo . in hemodialysis patients. all of participants will receive Epo. and identify various factors contributing to etiology of renal anemia in Epo- resistant patients.

Description:

Chronic kidney disease (CKD) is considered a public health problem worldwide with high incidence and prevalence rates.Anemia is one of the most frequent early complication of CKD. The main cause is erythropoietin (EPO) deficiency due to impaired kidney function However, other causes should be considered when the severity of anemia is inconsistent with the decrease in renal function; when there is evidence of iron deficiency or matching decreases in hemoglobin, leukopenia and/or thrombocytopenia are also found

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 1
• Est. completion date: May 2019
• Est. primary completion date: January 2019
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Patients greater than or equal to 18 years old with CKD on hemodialysis

Exclusion Criteria:

1. - Evidence of infections especial of vascular access .

2. - malnutrition and manifestation of iron, B12, folate and protein deficiency .

3. - any underling cause as;

• Hematologic malignances -Hemolytic anemia -

• Aplastic anemia (infection and/or bleeding with anemia)

• Solid tumors

• Bleeding (skin ,mucosal ,orificial)

• Evidence of mineral bone disease (CKD-MBD)

• Others

Related Conditions & MeSH terms

• Anemia
• ESRD
• Renal Anemia

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Renal anemia refractory to erythropoietin	1 .Measurement of Hemoglobin , feritin and reitculocyte of patient before treatmeant by Epo. 100IU per Kg per week-SC.; 2- Assessment to measure of hemoglobin of patient after treatment	1 months
Secondary	Renal anemia refractory to erythropoietin	1 .Measurement of Hemoglobin of patient by CBC before treatmeant by Epo. 100IU per Kg per week-SC?; 2- Assessment to hemoglobin of anemic patient during the specified post -dose period ,6months	6MONTHS