The Effect of Nocturnal Haemodialysis on Arterial Stiffness

End Stage Renal Disease Clinical Trial

Official title:

The Effect of Nocturnal Haemodialysis on Arterial Stiffness

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00641875
• Other study ID #: 2004.050
• Status: Completed
• Phase: N/A
• First received: March 17, 2008
• Last updated: April 23, 2015
• Start date: December 2005
• Est. completion date: February 2008

Study information

• Verified date: April 2015
• Source: Melbourne Health
• Contact: n/a
• Is FDA regulated: No
• Health authority: Australia: Human Research Ethics Committee
• Study type: Observational

Clinical Trial Summary

Arterial stiffness refers to the accumulation of extracellular deposits of matrix and calcium which reduce blood vessel compliance. Although there is growing evidence that increased arterial stiffness is associated with chronic kidney disease (CKD), its pathogenesis is unclear. Pulse wave velocity (PWV) and augmentation index (AIx) provide tools for estimating arterial stiffness, and therefore predicting cardiovascular morbidity and mortality. The aims of the study are: (1) compare the effects of nocturnal and conventional haemodialysis on arterial stiffness, and (2) examine the relationship between arterial stiffness and clinical and biochemical parameters.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: February 2008
• Est. primary completion date: February 2008
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• adult dialysis patients

• able to perform home nocturnal haemodialysis

Exclusion Criteria:

• age < 18 and > 80 years

• any patient who is anticipating a live renal transplantation in forthcoming 12 months

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Arterial Stiffness
• End Stage Renal Disease
• Kidney Diseases
• Kidney Failure, Chronic

Intervention

Procedure:
• Nocturnal Hemodialysis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Melbourne Health

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To purpose of this study is to evaluate the arterial stiffness in subjects who have undergone 12 months nocturnal haemodialysis.		12 months	No
Secondary	To examine the relationship between arterial stiffness and clinical and biochemical parameters		12 months	No