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Clinical Trial Summary

Rates of local disease control in patients with locally advanced esophageal cancer who are not candidates for surgical resection are suboptimal. Despite treatment with chemotherapy and radiation therapy approximately half of patients will develop recurrence of their cancer at the site of the original primary cancer. Salvage therapy options are largely ineffective and nearly all patients who develop local disease recurrence will succumb to their cancer. Recent clinical trials for lung cancer have demonstrated that local tumor control can be improved safely with accelerated hypofractionated radiation therapy regimens in order to achieve radiation dose intensification. This clinical trial aims to adapt those techniques and assess the safety of such a regimen for the treatment of inoperable thoracic esophageal cancers.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04046575
Study type Interventional
Source Washington University School of Medicine
Contact Gregory Vlacich, M.D., Ph.D.
Phone 314-362-8610
Email gvlacich@wustl.edu
Status Recruiting
Phase Phase 1
Start date November 7, 2019
Completion date September 30, 2027

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