| Eligibility |
Inclusion Criteria:
- patients with esophageal cancer confirmed by histology or cytology;
- according to TNM staging for ? period, previous untreated can be removed and
potentially resectable esophageal cancer patients;
- can eat more than liquid diet;No signs before esophageal perforation;No distant
metastasis;
- male or female, age 18 and 75 years old or less or more;
- ECOG PS 0 ~ 1 minute;
- is expected to survive period for 3 months or more,
- enough blood function: absolute neutrophil count (ANC) or 2 x 109 / L and the •
platelet count 100 x 109 / L or higher acuity 9 g/dL and hemoglobin;Liver function
- enough: upper limit of total bilirubin acuities were normal (ULN);AST and ALT acuities
were 2.5 times the upper limit of normal (ULN);Alkaline phosphatase 5 times the upper
limit of normal or less (ULN);
- enough renal function, serum creatinine or less normal limit (ULN) or calculated
creatinine clearance or 60 mL/min.
- basic normal ecg, no healing trauma;
- always not received anti-tumor drug treatment;
- ever had had surgery patients, request to study treatment began to have more than 4
weeks, and the patient has recovered;
- a complete uterus of female in the group within 28 days before the study must have a
negative pregnancy test results (except amenorrhea has 24 months).If the pregnancy
test from the first time for more than 7 days, is the need for urine pregnancy test
validation (within 7 days before the first delivery).
- prior to biological agents, especially e. coli genetically engineered products without
severe allergic reactions;
Exclusion Criteria:
- there is a clear taxol allergy history;
- pregnancy, nursing mothers, or have fertility but not women using contraception;
- the existing serious acute infection, and not be controlled;Or fester sex and chronic
infection, wound in delay no more;
- the original serious heart disease, including: higher risk of congestive heart
failure, unable to control arrhythmia, unstable angina, myocardial infarction, severe
valvular heart disease, and resistant hypertension;
- is not easy to control nerve, mental illness or mental disorders, compliance is poor,
can't cooperate with accounts and response to treatment;Primary brain tumors or CNS
metastases illness did not get a control, has obvious symptoms in cranial hypertension
or nerve spirit;
- with bleeding tendency;
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