Ulcer Bleeding After Band Ligation of Esophageal Varices

Status Not yet recruiting

Clinical Trial Summary

Primary Outcomes: assessment of incidence , risk factors and prognosis of post-banding ulcer bleeding following EVL in patients with liver cirrhosis. Secondary Outcomes: minimize post-banding ulcer bleeding

Clinical Trial Description

Esophageal variceal bleeding represents the most vital complication among patients with liver cirrhosis at rate of 5-15% per year. Endoscopic variceal ligation (EVL), either used as therapeutic in emergency or as prophylactic, is one of the best modalities used in EV treatment. The procedure is effective and generally safe. After banding, a superficial ulcer is formed, which usually heals in 2-3 weeks. The main complications of variceal banding are pain, dysphagia, fever, bleeding during the procedure and post banding ulcer bleeding (PBUB). The prevalence of PBUB is reported to be 3.6-15% . Rebleeding can be fatal, and is mainly resulted from early spontaneous slippage of the rubber bands, before occlusion of the varix with a mature thrombus, leaving an unhealed ulcer . The time frame of variceal rebleeding can be divided into very early rebleeding (within 5 days of acute bleeding), early rebleeding (within 6 weeks of acute bleeding), and delayed rebleeding. Previous reports showed that early rebleeding ranged from 30% to 40% within the first 6 weeks, and was significantly associated with the risk of death within 6 weeks. Therefore, the aim of this research is assessment of incidence , risk factors and prognosis of post-banding ulcer bleeding following EVL in patients with liver cirrhosis, in order to minimize post-banding ulcer bleeding. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06082219
Study type	Observational
Source	Assiut University
Contact	Amna Esmail Mohamed Tammam
Phone	+20 1145547952
Email	amnaesmail.145@gmail.com
Status	Not yet recruiting
Phase
Start date	January 1, 2024
Completion date	March 1, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT06017102` - Wired Magnetically Assisted Capsule Endoscopy and Esophageal Varices	N/A
Recruiting	`NCT03624517` - Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices	Phase 4
Recruiting	`NCT03989973` - Two-dimensional Shear-Wave Elastography Evaluate Esophageal Varices Bleeding Risk of Liver Cirrhosis
Completed	`NCT05485714` - Non-invasive Prediction of Esophageal Varices in Patients With Non-Alcoholic Fatty Liver Disease With Advanced Fibrosis
Completed	`NCT01851252` - MBT Versus HVPG in Identifying Responders to Portal Hypertension Therapy	Phase 1
Completed	`NCT01360515` - A Study of Disposable Transnasal Esophagoscope	N/A
Recruiting	`NCT04602663` - Optimal Time for Follow up After Variceal Band Ligation	N/A
Recruiting	`NCT04499898` - Carvedilol Versus Endoscopic Band Ligation for Primary Prophylaxis of Oesophageal Variceal Bleeding	Phase 2/Phase 3
Completed	`NCT00331188` - Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding	Phase 3
Enrolling by invitation	`NCT02767206` - Evaluation of Gastroesophageal Varices by Transnasal Endoscopy.	N/A
Enrolling by invitation	`NCT05781828` - Noninvasive Methods For Prediction of Esophageal Varices in Children
Not yet recruiting	`NCT05199038` - Comparison of 2 Days Versus 5 Days of Octreotide After Endoscopic Therapy in Preventing Early Esophageal Varices Rebleed : A Randomized Controlled Study	Phase 4
Recruiting	`NCT02740166` - Preventing Recurrent Bleeding After Eradication of Esophageal Varices	Phase 4
Completed	`NCT01893541` - PROPRANOLOL PLUS LIGATION REDUCES RECURRENCE OF ESOPHAGEAL VARICES?	Phase 4
Terminated	`NCT00485290` - Effect of Meal on Portal and Esophagus Variceal Pressure	N/A
Completed	`NCT01079416` - Study of Capsule Endoscopy to Determine the Accuracy for Detection of Esophageal Varices	N/A
Completed	`NCT01188733` - Efficacy of Long-acting Octreotide (Sandostatin LAR) in Reducing Portal Pressure in Patients With Cirrhosis	Phase 1/Phase 2
Not yet recruiting	`NCT04254822` - HVPG-Guided Therapy vs Carvedilol Plus Endotherapy for the Prevention of Esophageal Variceal Rebleeding in Cirrhotic Patients	N/A
Recruiting	`NCT03212872` - Blood Ammonia as Predictor for Esophageal Varices and Risk of Bleeding	N/A
Completed	`NCT03748563` - Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of EGV in Patients With Cirrhosis	N/A