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Esophageal Squamous Dysplasia clinical trials

View clinical trials related to Esophageal Squamous Dysplasia.

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NCT ID: NCT05028725 Recruiting - Clinical trials for Esophageal Squamous Cell Carcinoma

Novel Strategy for Early Detection of Esophageal Squamous Cell Carcinoma

Start date: May 16, 2022
Phase: N/A
Study type: Interventional

In the current protocol, we propose a study to evaluate a novel, combined esophageal sponge-methylation biomarker strategy for the early detection of esophageal squamous cell carcinoma (ESCC) as well as its precursor, esophageal squamous dysplasia (ESD). This strategy leverages the 'EsophaCap', a swallowable, retrievable sponge, with subsequent evaluation of the sample using a novel molecular biomarker assay. This biomarker assay evaluates methylation levels in select genes, which have been shown to differ significantly between ESCC cases and controls in pilot studies. Detection of methylation markers highly associated with ESCC could help identify patients with concurrent ESCC or at high risk of imminently developing this condition. If successful, this strategy could result in a paradigm shift for esophageal cancer control strategies in Tanzania and other high-incidence ESCC regions.

NCT ID: NCT02534233 Active, not recruiting - Esophageal Cancer Clinical Trials

Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium

ColdPlay2
Start date: April 2015
Phase: N/A
Study type: Interventional

Assess Cryoablation (CryoBalloon Ablation cryotherapy) for treatment of Dysplastic Barrett's Esophagus, Esophageal Squamous Dysplasia and early Esophageal Cancer. The cryoablation treatment will be offered as an alternative to standard ablation therapies such as Radiofrequency Ablation, Argon Plasma Coagulation and carbon dioxide Cryotherapy).

NCT ID: NCT02146508 Suspended - Esophageal Cancer Clinical Trials

Endoscopic Prevention of Esophageal Cancer at Tenwek Hospital

EXPECT
Start date: June 2013
Phase: N/A
Study type: Interventional

Esophageal cancer is common in Kenya. The precursor of esophageal cancer is esophageal squamous dysplasia (ESD). In this study, persons known to have ESD will undergo endoscopic removal or ablation of ESD in order to prevent development of esophageal cancer.