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Clinical Trial Summary

This is an open-label, multicenter, phase Ib study to evaluate the safety, tolerability, and preliminary efficacy of AN0025 in combination with chemoradiotherapy (CRT) in patients with locally advanced/locally recurrent esophageal cancer. This study will enroll different cohorts of patients based on the assessment of original lesions, including patients that can be surgically resected with potential (but primary resection without CRT is unlikely to achieve clear margins as defined by MRI), patients with unresectable locally advanced esophageal cancer or esophagogastric junction cancer, and patients with unresectable locally recurrent esophageal cancer or esophagogastric junction cancer where the recurrent region has not received radiotherapy. Histologic classification can be squamous cell carcinoma or adenocarcinoma.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05191667
Study type Interventional
Source Adlai Nortye Biopharma Co., Ltd.
Status Not yet recruiting
Phase Phase 1
Start date January 2022
Completion date December 2025

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