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Clinical Trial Summary

The investigators propose to compare recurrence-free survival in patients having potentially curative (Stages 1-3) surgery for esophageal cancer who will be randomly assigned to propofol-based total intravenous anesthesia or sevoflurane-based balanced general anesthesia.


Clinical Trial Description

The investigators will test the primary hypothesis that recurrence-free survival after esophageal cancer surgery is longer in patients randomized to propofol-based total intravenous anesthesia than to volatile sevoflurane anesthesia. The investigators will test the secondary hypotheses that propofol-based total intravenous anesthesia: 1) speeds discharge from the ICU; 2) speeds discharge from the hospital; and, 3) improves the quality of recovery, as assessed by QoR-15 on postoperative day 2. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04513808
Study type Interventional
Source The Cleveland Clinic
Contact Daniel I Sessler, MD
Phone 216-870-2620
Email DS@CCF.org
Status Recruiting
Phase Phase 3
Start date August 15, 2020
Completion date December 2027

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