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Safety and Feasibility of Irradiation and Nivolumab in Esophageal Cancer (INEC)

Esophageal Cancer Clinical Trial

Official title:
Safety and Feasibility of Irradiation and Nivolumab in Esophageal Cancer (INEC-study) - a Phase I/II Trial

Clinical Trial Summary

Three parallel cohort, multicenter, open-label, phase I/II clinical trial to analyze the safety and feasibility of PD-1 inhibition with Nivolumab given concomitantly with standard radiotherapy regimens in the treatment of esophageal cancer

Clinical Trial Description

Three parallel cohort, multicenter, open-label, phase I/II clinical trial to analyze the safety and feasibility of PD-1 inhibition with Nivolumab given concomitantly with standard radiotherapy regimens in the treatment of esophageal cancer. Cohort A: Advanced/inoperable esophageal cancer, eligible for palliative radiotherapy of the primary tumor. Cohort B: Inoperable esophageal cancer without metastases, eligible for definitive chemoradiotherapy Cohort C: Operable esophageal cancer eligible for neoadjuvant chemoradiotherapy ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03544736
Study type Interventional
Source Oslo University Hospital
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date April 26, 2018
Completion date December 31, 2040
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