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Microbiome Involvement With Barrett's Esophagus and Progression to Esophageal Adenocarcinoma

Esophageal Cancer Clinical Trial

Official title:
Microbiome Involvement With Barrett's Esophagus and Progression to Esophageal Adenocarcinoma

Clinical Trial Summary

This study will examine the hypothesis that altered esophageal microbiome leads to the development of esophageal adenocarcinoma (EAC). The aims of the project are, firstly the confirmation of relational data on the study cohort, using the methods developed and applied at the laboratory at University of Queensland Diamantina Institute (UQDI). Second, to generate a tissue microarray resource future tissue in-situ validation of microbes. And finally, to develop a biobank of clinical isolates of relevant esophageal microbes for future functional studies.

Clinical Trial Description

Gastroesophageal reflux disease, GERD, can lead to a change of the esophagus lining to a protective cell type, termed Barrett's esophagus (BE). A diagnosis of BE greatly increases the risk of developing esophageal adenocarcinoma (EAC). The incidence of EAC has been rapidly rising in the last 30 years, and the cancer has a high mortality rate. Understanding the involvement of the esophageal microbiota could lead to prevention strategies to this increasing health concern.

This study will examine the hypothesis that altered esophageal microbiome leads to the development of esophageal adenocarcinoma (EAC). The aims of the project are, firstly the confirmation of relational data on the study cohort, using the methods developed and applied at the laboratory at University of Queensland Diamantina Institute (UQDI). Second, to generate a tissue microarray resource future tissue in-situ validation of microbes. And finally, to develop a biobank of clinical isolates of relevant esophageal microbes for future functional studies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03216135
Study type Observational
Source Ochsner Health System
Contact Virendra Joshi, MD
Phone 504-842-7690
Email vjoshi@ochsner.org
Status Recruiting
Phase N/A
Start date July 20, 2017
Completion date December 2017
View Details
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