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Dose Escalation of Neoadjuvant Proton Beam Radiotherapy With Concurrent Chemotherapy in Locally Advanced Esophageal Cancer

Esophageal Cancer Clinical Trial

Official title:
Phase I Dose Escalation of Neoadjuvant Proton Beam Radiotherapy With Concurrent Chemotherapy in Locally Advanced Esophageal Cancer

Clinical Trial Summary

Patients with esophageal cancer to be treated with concurrent preoperative proton therapy along with carboplatin and paclitaxel.

Clinical Trial Description

1. To identify the maximally tolerated radiation dose (MTD) of dose-escalated proton radiotherapy in combination with carboplatin/paclitaxel in the preoperative setting for esophageal cancer. 2. To estimate pathologic response rates by esophagectomy surgical specimens after escalated doses of chemoradiotherapy. 3. To assess the utility of circulating tumor cells and tumor vesicles as biomarkers to predict treatment response to chemoradiotherapy ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02213497
Study type Interventional
Source Abramson Cancer Center at Penn Medicine
Contact
Status Active, not recruiting
Phase Phase 1
Start date April 2014
Completion date December 31, 2024
View Details
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