Esophageal Cancer Clinical Trial
Official title:
A Phase I Study of S-1 With Concurrent Radiotherapy in Elderly Patients With Esophageal Cancer
Elderly patients with esophageal cancer will receive thoracic radiation therapy 54Gy over 30 fractions, and concurrent with s-1 on days 1-14 and 29-42 at the following dosages: 60, 70, and 80 mg/m(2)/day.
Purpose:evaluated the dose-limiting toxicity and recommended dose of S-1 for a future phase
II study when administered concurrently with thoracic radiation in elderly patients (>70
years old) with esophageal Cancer.
Methods:S-1 was administered on days 1-14 and 29-42 at the following dosages: 60, 70, and
80mg/m(2)/day. Thoracic radiation therapy was administered in 1.8Gy fractions five times
weekly to a total dose of 54 Gy.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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