Clinical Trials Logo

Esophageal Atresia clinical trials

View clinical trials related to Esophageal Atresia.

Filter by:

NCT ID: NCT05129930 Completed - Critical Illness Clinical Trials

Fluid Overload and Pulmonary Function

Start date: December 1, 2020
Phase:
Study type: Observational

Esophageal atresia is a rare but severe malformation, and it requires early surgery. Coloesophagoplasty is surgical repair of the esophageal with an isoperistaltic transverse colon graft. In the postoperative period after coloesophagoplasty children require careful monitoring of fluid balance, because clinically significant fluid overload can lead to dysfunction of various organs and systems.

NCT ID: NCT04932746 Completed - Esophageal Atresia Clinical Trials

The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.

RCT
Start date: March 1, 2021
Phase: N/A
Study type: Interventional

The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be intravenous infusion of normal saline. We will take three samples of arterial blood gas (ABG) during the surgery at certain times. We record the hemodynamic values, PaO2, and calculate the value of the shunt Qs / Qt.

NCT ID: NCT04911036 Recruiting - Atresia, Esophageal Clinical Trials

Study of the Effect of the Time of Diagnosis (Antenatal vs. Postnatal) on the Post-traumatic Reactions of Parents of Children Undergoing Oesophageal Atresia Surgery "

DANAO
Start date: May 6, 2021
Phase:
Study type: Observational

This is an observational, national multicentre (34 centres involved), cross-sectional study in psychology whose objective is to describe and compare the levels of post-traumatic reactions of mothers to the announcement of their child's EA diagnosis. An ancillary study will be carried out among the fathers present who agree to participate in the study.

NCT ID: NCT04901546 Completed - Esophageal Atresia Clinical Trials

Esophageal Atresia: a Natural Experiment of the Effects of Oral Inoculation on the Gut Microbiome

Start date: May 15, 2021
Phase: N/A
Study type: Interventional

The purpose of this study is to understand changes of the gut microbiome due to esophageal atresia. The intervention will be to give a patient his or her own saliva through their gastrostomy tube (directly into the stomach) to observe if this can normalize microbial colonization of the gut.

NCT ID: NCT04522193 Not yet recruiting - Dumping Syndrome Clinical Trials

Dumping Syndrome and Esophageal Atresia

DUMTORING
Start date: November 2021
Phase: N/A
Study type: Interventional

Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood. This is also an affection difficult to diagnose, because it only occurs after meals and can be inconstantly present. To date, their is only symptomatic treatment for DS. This study aims to understand its pathological mechanisms so as to better treat it and avoid its consequences. Oesophageal atresia patients enrolled in this study will benefit from a continuous glycemic monitoring, a continuous cardiac monitoring, and an a gastric emptying scintigraphy at the age of 3 months

NCT ID: NCT04259528 Not yet recruiting - Esophageal Atresia Clinical Trials

Endoscopic Ultrasound Findings in Esophageal Atresia Following Surgical Repair

Start date: March 1, 2020
Phase: N/A
Study type: Interventional

Children with esophageal atresia who undergo surgical repair are at risk for anastomotic stricture following surgery. Esophageal stricture can be treated with serial endoscopic dilation but may ultimately need surgical resection if the stricture proves refractory to therapy. Several risk factors have been reported for development of recalcitrant stricture, but to date, no studies have specifically examined the relationship between anastomotic thickness and echotexture at time of initial postoperative endoscopy and treatment outcomes. Other risk factors that have been implicated in the development of recalcitrant stricture include gastroesophageal reflux disease, anastomotic leak, long-gap esophageal atresia, and gestational age. Moreover, it is poorly understood how esophageal layers alter and progress with repeated therapeutic dilation. The investigator hypothesize that the initial thickness and echotexture will help determine therapeutic outcome. It will also help us understand the progression of esophageal echotexture following therapeutic dilation.

NCT ID: NCT04183621 Recruiting - Clinical trials for Esophageal Atresia With Tracheoesophageal Fistula

Swallowing, Feeding and Eating in Children Born With Oesophageal Atresia/Trache-oesophageal Fistula (OA/TOF)

SaFE
Start date: December 15, 2020
Phase:
Study type: Observational

How does oesophageal atresia/trache-oesophageal fistula affect feeding and swallowing in the first year of life? Approximately 150 babies a year are born with oesophageal atresia and/or trache-oesophageal atresia. Oesophageal atresia occurs when the oesophagus (food pipe) fails to join up during early foetal development. Trache-oesophageal fistula describes an abnormal connection that forms between the oesophagus and trachea (wind pipe). When the baby feeds, milk cannot pass into the stomach but can pass into the lungs. Surgery is needed within the first few days of life and is extremely successful, with 90-95% of babies surviving. However, approximately 50-80% of babies will have ongoing feeding or swallowing difficulties resulting in choking, chest infections and pneumonia. They can also lead to food refusal, distress at mealtimes and parental anxiety. Currently there is limited understanding of: - the exact nature of the feeding and swallowing difficulties - the risk factors for developing difficulties - the impact on parents. This study will address these issues through two complimentary projects: Project 1: A study of swallow physiology Babies with oesophageal atresia and/or trache-oesophageal fistula who have surgery at Great Ormond Street Hospital will be invited to have a detailed swallow assessment using videofluoroscopy (video x-ray) and high resolution impedance manometry (a pressure monitor) at 2-4 months of age and at 8-12 months of age. Results will be compared to parent report of feeding at 1 year old. Project 2: A study of the impact on parental well-being This study will be carried out in conjunction with the 'TOFS' support group. A Facebook page will be used to carry out an online forum. Parents of any child who has had TOF/OA will be invited to share their experiences of establishing feeding. This information will be used to develop a questionnaire to look at how wide-ranging these experiences are.

NCT ID: NCT04136795 Not yet recruiting - Esophageal Atresia Clinical Trials

Evaluation of the Respiratory Impact After Conventional or Minimally Invasive Esophageal Atresia Surgery

RestriMIS
Start date: January 1, 2020
Phase:
Study type: Observational

Right thoracotomy, conventional approach to esophageal atresia repair, leads to up to 60% radiological chest wall sequelae anomalies. The impact of these anomalies on the patient's respiratory function remains unknown. Minimally invasive thoracic surgery considerably reduces this rate. The primary objective of this study is to assess the occurrence of restrictive lung disease in patients with type III esophageal atresia depending on the type of surgical approach (Conventional or minimally invasive). The primary endpoint will be he occurrence of restrictive lung disease , objectified by pulmonary function tests (PFTs), carried out according to the current national guidelines (PNDS = protocole national de diagnostic et de soins).

NCT ID: NCT04072419 Recruiting - Clinical trials for Enhanced Recovery After Surgery

Application of Enhanced Recovery After Surgery for Congenital Esophageal Atresia During Perioperative Period

ERASforCEA
Start date: September 2019
Phase:
Study type: Observational

The purpose of this prospective cohort study is to evaluate the safety and effectiveness of enhanced recovery after surgery (ERAS) to perform routine thoracoscopic repair for elective esophageal atresia type C

NCT ID: NCT03999008 Not yet recruiting - Esophageal Atresia Clinical Trials

Oral Viscous Budesonide in Anastomotic Stricture After Esophageal Atresia Repair (OVB in EA)

OVB in EA
Start date: June 1, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to perform a multicentre, prospective, randomized, placebo controlled, double-blinded study to demonstrate the potential and beneficial effects of OVB in the prevention of recurrence of anastomotic stricture in children operated for esophageal atresia with an anastomotic stricture.