The Study on the Esketamine in the Treatment of Postherpetic Neuralgia

Status Recruiting

Clinical Trial Summary

Herpes zoster (HZ) is an acute herpetic skin disease caused by the reactivation of the varicella-zoster virus (VZV) latent in the sensory ganglia. Postherpetic neuralgia (PHN) often occurs after herpes zoster heals and persists for a long time. At present, clinically anticonvulsants (such as gabapentin, pregabalin) and antidepressants (such as amitriptyline) are clinically first-line drugs for the treatment of PHN, which are not usually effective to treat PHN well, as well as to alleviate patients' bad mental symptoms. Esketamine, as a well-known N-methyl-D-aspartate receptor inhibitor, has both analgesic and antidepressant effects with extremely few incidence of respiratory depression, delirium, hallucinations, nausea and vomiting. Therefore, we hypothesize that esketamine could relieve PHN and Anxiety and depression-like symptoms symptoms in patients with PHN. This study intended to compare the efficacy of pregabalin, amitriptyline combined with esketamine therapy and pregabalin combined with amitriptyline therapy for alleviating PHN, and to further explore the feasibility and safety of esketamine in the treatment of PHN as well as underlying the mechanism of esketamine on the PHN.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04664530
Study type	Interventional
Source	Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact	Lieju Wang, Master
Phone	18758131223
Email	11518264@zju.edu.cn
Status	Recruiting
Phase	Phase 4
Start date	November 25, 2020
Completion date	December 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04546334` - Erector Spinae Plane Block in Post-herpetic Neuralgia	N/A
Completed	`NCT01688947` - Analgesic Efficacy and Safety of V116517 in Subjects With Moderate to Severe Chronic Pain Due to Postherpetic Neuralgia (PHN)	Phase 2
Terminated	`NCT01744522` - Leech Therapy for Postherpetic Neuralgia	N/A
Completed	`NCT00478179` - Study of a Bupivacaine Patch (Eladur™) to Treat Post- Herpetic Neuralgia	Phase 2
Completed	`NCT00566904` - New Topical Treatment for Continued Pain After Shingles	Phase 1
Completed	`NCT04099706` - Treatment of Chronic Postherpetic Pain With Autologous Fat Grafting - A RCT	N/A
Terminated	`NCT01603394` - Pilot Study Of Pregabalin And Prediction Of Treatment Response In Patients With Postherpetic Neuralgia	Phase 4
Completed	`NCT01251211` - Botulinum Toxin in Peripheral Neuropathic Pain	Phase 4
Completed	`NCT01228838` - Study of NGX-1998 for the Treatment of Postherpetic Neuralgia	Phase 2
Completed	`NCT00612105` - Safety/Efficacy Study of Retigabine vs. Placebo in Post-Herpetic Neuralgia (PHN)	Phase 2
Recruiting	`NCT04560361` - The Analgesic Effect of Electroacupuncture on Postherpetic Neuralgia	N/A
Recruiting	`NCT05568186` - Correlation Between Thermal Patterns of Infrared Thermal Imaging and Clinical Phenotype in Patients With Postherpetic Neuralgia
Active, not recruiting	`NCT01508676` - Effects of Pennsaid on Clinical Neuropathic Pain	N/A
Completed	`NCT00885586` - Acupuncture in Herpes Zoster Neuralgia (ACUZoster)	Phase 4
Completed	`NCT00981227` - Efficacy and Safety of Eslicarbazepine Acetate as Therapy for Patients With Post-Herpetic Neuralgia	Phase 2
Completed	`NCT00576108` - A 2 Week Study of Topical KD7040 in the Treatment of Postherpetic Neuralgia (PHN)	Phase 2
Completed	`NCT00238511` - An Open-Label Follow-on Trial to Assess the Long-Term Safety and Efficacy of Oral SPM 927 in Subjects With Postherpetic Neuralgia (PHN)	Phase 2
Completed	`NCT00007501` - Shingles Prevention Study	Phase 3
Completed	`NCT04594226` - Electroacupuncture Therapy for Treating Postherpetic Neuralgia	N/A
Completed	`NCT05140863` - To Evaluate the Efficacy and Safety of HSK16149 Capsule in Chinese Patients With Postherpetic Neuralgia	Phase 3