Erythropoietic Protoporphyria Clinical Trial
OBJECTIVES:
I. Determine the long-term efficacy and safety of L-cysteine in the prevention
photosensitivity in patients with erythropoietic protoporphyria.
PROTOCOL OUTLINE: This is a phase III study, lasting 3 years; 1996-1999. Patients are
administered L-cysteine orally twice daily, 2 capsules with breakfast and 2 with lunch.
Patients fill in questionnaires and diary sheets about their reaction to sunlight exposure,
and have blood tested 3 times a year.
Completion date provided represents the completion date of the grant per OOPD records
;
Primary Purpose: Treatment
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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Phase III Confirmatory Study in Erythropoietic Protoporphyria (EPP)
|
Phase 3 | |
Active, not recruiting |
NCT05308472 -
Study of Bitopertin to Evaluate the Safety, Tolerability, Efficacy, and PPIX Concentrations in Participants With EPP
|
Phase 2 | |
Completed |
NCT00004831 -
Study of Cysteine Hydrochloride for Erythropoietic Protoporphyria
|
N/A | |
Completed |
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Iron Therapy in Erythropoietic Protoporphyria
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||
Completed |
NCT01605136 -
Phase III Confirmatory Study in Erythropoietic Protoporphyria
|
Phase 3 | |
Completed |
NCT01422915 -
Sorbent Therapy of the Cutaneous Porphyrias
|
Phase 2/Phase 3 | |
Completed |
NCT04053270 -
Multicentre Phase III Erythropoietic Protoporphyria Study
|
Phase 3 | |
Recruiting |
NCT06388642 -
Pharmacokinetics of Afamelanotide in EPP Patients
|
Phase 1/Phase 2 | |
Recruiting |
NCT05020184 -
Effect of Oral Cimetidine in the Protoporphyrias
|
Phase 2 | |
Completed |
NCT01688895 -
Erythropoietic Protoporphyrias: Studies of the Natural History, Genotype-Phenotype Correlations, and Psychosocial Impact
|
||
Completed |
NCT04578496 -
A Safety Extension Study in Patients With Erythropoietic Protoporphyria (EPP)
|
Phase 3 | |
Recruiting |
NCT00206869 -
Does Exercise and Heat Increase the Lightsensibility in Patients With Erythropoietic Protoporphyria
|
N/A | |
Recruiting |
NCT05780840 -
Protection Against Visible Light by Dihydroxyacetone in Erythropoietic Protoporphyria
|
N/A | |
Completed |
NCT02979249 -
Oral Iron for Erythropoietic Protoporphyrias
|
N/A | |
Enrolling by invitation |
NCT05883748 -
Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP
|
Phase 2/Phase 3 | |
Completed |
NCT01097044 -
Phase II Confirmatory Study in Erythropoietic Protoporphyria (EPP)
|
Phase 2 | |
Completed |
NCT03682731 -
Light Exposure Patterns and Symptoms Among Patients With Erythropoietic Protoporphyria
|