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Erythropenia (Diagnosis) clinical trials

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NCT ID: NCT01295801 Recruiting - Cytopenias Clinical Trials

Vitamin B6 on Relieving Linezolid-associated Cytopenias

Start date: November 2010
Phase: N/A
Study type: Observational

Linezolid is the first approved synthetic oxazolidinone that is active against multidrug-resistant Gram-positive pathogens. Because of its significant efficacy, linezolid is widely used in clinical treatment. However, the side effects of linezolid commonly lead to anemia and thrombocytopenia. This hematological toxic effects limit its prolonged used. The investigators have found that Vitamin B6 application, as a preventive, auxiliary therapy, can relieve anemia and thrombocytopenia. The present study was designed to verify the effects of Vitamin B6 in the prevention of linezolid-associated cytopenias and investigate its mechanism.