Erythroblastosis, Fetal Clinical Trial
Official title:
Randomized Controlled Trial on the Use of EPO to Reduce Top-up Transfusions in Neonates With Red Blood Cell Alloimmunization Treated With Intrauterine Transfusions
Up to 80% of infants with hemolytic disease due to maternal alloimmunization, treated with IUT, require at least one top-up transfusion for late anemia during the first 3 months of life. Erythropoietin deficiency is also considered as a possible contributing factor to late anemia and therefore we will assess the role of EPO (darbepoetin alfa) in the treatment of these infants.
The mainstay of antenatal treatment of fetal anemia due to red cell alloimmunization is
(serial) IUT. The mainstay of postnatal treatment in HDN is (1) intensive phototherapy and
exchange transfusion to treat hyperbilirubinemia and prevent kernicterus, and (2) top-up
transfusions to treat anemia. Up to 80% of infants with HDN treated with IUT require at least
one top-up transfusion for late anemia during the first 3 months of life.
Several risk factors for late anemia have been reported, including serial IUT (due to bone
marrow suppression), severity of HDN, reduced use of exchange transfusions during the
neonatal period and reduced survival of transfused red blood cells. Finally, erythropoietin
deficiency is also considered as a possible contributing factor to late anemia.
EPO has been increasingly used in neonates to prevent or reduce neonatal anemia without short
or long-term adverse effects. Several small studies and casuistic reports suggest that
neonates with HDN may benefit from treatment with EPO to reduce the risk of delayed anemia
and subsequent top-up transfusions. However, other authors found that EPO may be less
effective than expected. Due to the lack of evidence, routine use of EPO is currently not
recommended. To determine a role for EPO in this group of patients, a well-designed
randomized controlled clinical trial of sufficient sample size is required. Potentially, EPO
stabilizes the hemoglobin levels of these infants and thus prevents top-up transfusions and
extra admissions, creating a more stable and natural postnatal course for patients with HDN.
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Status | Clinical Trial | Phase | |
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Completed |
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Phase 4 | |
Completed |
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