Lyme Disease Clinical Trial
Official title:
Tick Borne Diseases in Norwegian General Practice. A Randomized, Controlled Trial for Treatment of Erythema Migrans in Norwegian General Practice. A Comparison of Phenoxymethylpenicillin, Amoxicillin and Doxycycline.
Tick borne diseases are increasing in Norway. Lyme borreliosis is the most common infection. Erythema migrans is mainly diagnosed and treated in general practice. There is disagreement about what antibiotic treatment that should be given. An RCT with the three most common antibiotics used, will support data for revision of national guidelines.
Comparison of phenoxymethylpenicillin, doxycycline and amoxicillin for Erythema migrans in Norwegian general practice. Every patient receives 14 days of antibiotic treatment. There are blood samples for measurement of Borrelia antibody level at day 1, 14 and 90 and questionnaires on subjective health complaints (SHC) at day 1, 90 and 360. Side symptoms and side effects are registered. For volunteers there is an additional PCR-analysis on punch biopsy from the EM for subgrouping of the Borrelia bacteria. TBE-antibodies are measured on day 14. Antibody levels and SHC-scores are compared to healthy blood donors. ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01207739 -
Persistent Lyme Empiric Antibiotic Study Europe
|
Phase 4 | |
| Terminated |
NCT04577053 -
PEMF Therapy to Treat Lingering Symptoms of Lyme Disease After Treatment With Antibiotics
|
N/A | |
| Completed |
NCT04867473 -
Feasibility of Teleyoga for Treatment of Lyme Disease
|
N/A | |
| Recruiting |
NCT04038346 -
Symptomatic Management of Lyme Arthritis
|
Phase 3 | |
| Completed |
NCT01143558 -
Searching for Persistence of Infection in Lyme Disease
|
Early Phase 1 | |
| Withdrawn |
NCT04318925 -
Evaluation and Follow-up of People With Tick-borne Diseases
|
||
| Terminated |
NCT03581279 -
Detection of Borrelia Bacteria in Early Stage Lyme Borreliosis Using the T2Lyme Panel
|
N/A | |
| Enrolling by invitation |
NCT05041595 -
Lyme Disease Diagnostic Assay - Collection of Whole Blood
|
||
| Recruiting |
NCT03981874 -
Peripheral Facial Paralysis Sequelae in Lyme Disease Among Children
|
N/A | |
| Recruiting |
NCT03963635 -
Novel Diagnostics for Early Lyme Disease
|
||
| Terminated |
NCT03084614 -
CD8 Reactivity to Microorganisms in Blood and Breast Milk
|
||
| Recruiting |
NCT04835792 -
Biomarker Study of Previously Treated Lyme Disease Volunteers in Comparison to Healthy Volunteers
|
||
| Recruiting |
NCT06397794 -
Navigating Pregnancy and Parenthood With Lyme Disease
|
||
| Recruiting |
NCT04148222 -
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease
|
||
| Terminated |
NCT03201042 -
Lyme Test Indication Combinations (LyTIC) Study
|
||
| Terminated |
NCT00958139 -
Passive Prophylaxis of Lyme Disease Using Permethrin Treated Clothes
|
Phase 3 | |
| Recruiting |
NCT00001539 -
A Comprehensive Clinical, Microbiological and Immunological Assessment of Patients With Suspected Post Treatment Lyme Disease Syndrome and Selected Control Populations
|
||
| Recruiting |
NCT03501407 -
Understanding Tick-borne Diseases
|
||
| Completed |
NCT04422314 -
ImmuneSense Lyme Study
|
||
| Recruiting |
NCT05312619 -
The Burden of Lyme Disease (BOLD) in a Pandemic - Insights From an Online Cross-sectional and Prospective Cohort Survey
|