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Clinical Trial Summary

The PamiAP will be a Phase II, single-arm, open label study to explore the efficacy and safety of Pamiparib treatment in patients with Epithelial Ovarian Cancer(EOC) who have had exposure to prior a PARP (poly(ADP-ribose)-polymerase) inhibitor


Clinical Trial Description

The landscape for treatment of Epithelial Ovarian Cancer(EOC) is rapidly changing. With the release of data from numerous studies exploring the role of PARP (poly(ADP-ribose)-polymerase) inhibitor as maintenance and treatment, approval has expanded significantly in recent years. However, with the widespread exposure of PARP inhibitor in the patients, whether another PARP inhibitor can be reused in patients with PARP inhibitor resistance or disease progression. We have no data regarding the efficacy or safety of a PARP inhibitor retreatment in patients who have had exposure to prior a PARP inhibitor. The objective of this study was to evaluate the efficacy and safety of Pamiparib in patients with EOC who had previously been treated with PARP inhibitor, and to explore the characteristics of patients who responded to PARP inhibitor again. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05489926
Study type Interventional
Source Zhejiang Cancer Hospital
Contact
Status Active, not recruiting
Phase Phase 2
Start date August 16, 2022
Completion date December 2024

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