Epithelial Ovarian Cancer Clinical Trial
Official title:
A Phase I Safety Study of Farletuzumab (MORAb-003), Carboplatin and Pegylated Liposomal Doxorubicin (PLD) in Subjects With Platinum-sensitive Ovarian Cancer
The purpose of this study is to evaluate whether combination therapy with farletuzumab (MORAb-003), carboplatin, and pegylated liposomal doxorubicin (PLD) is safe.
Farletuzumab (MORAb-003) is a monoclonal antibody that has the potential to be an effective
agent against epithelial ovarian cancer (including primary fallopian tube and peritoneal
adenocarcinoma) in combination with other drugs. Farletuzumab works by a different mechanism
from other cancer therapeutics and has been shown to be well tolerated. This study allows
the opportunity to determine if the combination therapy of farletuzumab, carboplatin, and
PLD
1. is safe, or
2. to assess the potential drug-drug interaction, and
3. to prolong response to chemotherapy.
;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label
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