Epistaxis Clinical Trial
Official title:
Treatment of Nasal Staphylococcus Aureus Colonization in Patients With Hereditary Hemorrhagic Telangiectasia With Recurrent Epistaxis.
Compare the frequency of epistaxis and quality of life related to nasal bleeding in patients with HHT colonized with sataphylococo before and after being treated with mupirocin ointment.
Hereditary hemorrhagic telangiectasia is a vascular dysplasia characterized by the
development of mucocutaneous telangiectasia and arteriovenous malformations in organs such
as brain, lung, liver and tube digestivo. Is considered a rare disease, although It means
that there is a substantial underdiagnosis. The overall prevalence is 1/5000.
Approximately 60% of the general population hosts strains of Staphylococcus aureus (S.
aureus) intermittently and are called intermittent carriers, 20% represent persistent
carriers harboring the same strain of S. aureus and 20% of the population are never
carriers.
On this concept, one might think that HHT patients in whom there is an active and
pathological vascular remodeling that causes bleeding, and inflammation is a known activator
of abnormal angiogenesis; reducing an inflammatory factor as microbial through the
eradication of nasal S. aureus could be useful to reduce bleeding in this population,
directly impacting on quality of life.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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