Epiphora Clinical Trial
Official title:
Prospective Clinical Evaluation of Dacryocystorhinostomy (DCR) With Lacrimal Intubation
The purpose of study is to investigate the safety and efficacy of lacrimal silicone intubation for the management of epiphora.
Epiphora is an overflow of tears,usually caused by insufficient drainage of the tear film
from the eye.The most common cause is a blockage of the lacrimal ducts located next to the
nose, but the condition may also result from the excessive production of tears. Epiphora is
a symptom rather than a disease and may be caused by a variety of conditions.
30 subjects will be recruited for this study, informed consent will be taken from the
willing subjects. Complete ophthalmic evaluation would be performed including visual acuity.
Diagnosis would be made on history of epiphora, regurgitation test, lids examination, nasal
examination, probing and syringing. Standard procedure of Dacryocystorhinostomy (DCR) would
be adopted in all cases with lacrimal intubation.
Syringing will be done on first follow up visit and skin sutures will also be removed.
Tightness and mobility of the silicone tube will be checked. The tube is kept in place for
3-6 months according to need and then finally removed. The patency of lacrimal passage will
be investigated by irrigation. A successful outcome will be defined as resolution of
symptoms like epiphora and discharge and a patent lacrimal system on irrigation.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04833452 -
Comparative Study Between Wide and Narrow Fenstrum Endoscopic DCR
|
N/A | |
| Completed |
NCT02240615 -
The Sinopsys Lacrimal Stent for Lacrimal System Repair in Epiphora
|
Phase 0 | |
| Suspended |
NCT03705000 -
SLlt Stent II Lacrimal Stent for the Treatment of Nasolacrimal Duct Obstruction
|
N/A | |
| Recruiting |
NCT05663684 -
Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?
|
Phase 4 | |
| Terminated |
NCT04229771 -
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
|
Phase 4 | |
| Active, not recruiting |
NCT02849093 -
Optical Coherence Tomography of Ocular Structures in Epiphora and Dry Eye Syndrome.
|
N/A | |
| Withdrawn |
NCT00824811 -
Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel
|
Phase 2 | |
| Completed |
NCT00266838 -
Prevention of Docetaxel Induced Dacryostenosis
|
Phase 1 | |
| Completed |
NCT03731143 -
Management of Lower Punctal Stenosis.
|
N/A | |
| Active, not recruiting |
NCT04680078 -
Placement of Three Interrupted Sutures After Triangular Three-snip Punctoplasty
|
N/A | |
| Completed |
NCT01282541 -
Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora
|
Phase 2 | |
| Completed |
NCT02503956 -
Perforated Punctal Plugs for Treatment of Papillary Conjunctivitis in Otherwise Healthy Patients
|
N/A | |
| Completed |
NCT04637633 -
Topical Cyclosporine-A for Management of Epiphora
|
Phase 2/Phase 3 | |
| Withdrawn |
NCT03266081 -
Bupivacaine Epiphora Trial
|
Phase 2 | |
| Completed |
NCT01766232 -
Lacrimal Drainage Resistance Study
|
N/A |