A Clinical Study of Epilepsy Localization and Prognosis Based on PET and Resting-state fMRI

Epileptic Seizure Clinical Trial

Official title:

A Clinical Study of Epilepsy Localization and Prognosis Based on Positron Emission Tomography and Resting-state Functional Magnetic Resonance Imaging

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05567042
• Other study ID #: 20222137
• Status: Not yet recruiting
• Start date: October 2022
• Est. completion date: July 2024

Study information

• Verified date: October 2022
• Source: Xijing Hospital
• Contact: Lei Ma, doctor
• Phone: 13325437929
• Email: shuangshuang9904[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

1. By following up the prognosis of surgical patients, the application value of Cortex ID quantitative analysis in the localization of epilepsy foci was studied.

2. By studying the correlation between autonomic nerve function and epilepsy neural network in epilepsy patients, and analyzing the differences between different epilepsy patients, it can provide more information for judging the prognosis of epilepsy patients.

Description:

This study included diagnostic trials and case-control studies, which were observational studies with no intervention. First, the demographic and clinical information of epilepsy patients in the Neurology Department of Xijing Hospital were collected, including gender, age, age of onset, course of epilepsy, seizure performance before treatment, seizure frequency before treatment, type and dose of antiepileptic drugs, past history, Family history, etc., as well as imaging, EEG, quality of life, and neuropsychological assessment, etc. were collected; secondly, functional magnetic resonance imaging (fMRI) and 24-hour Holter monitoring were performed on patients who met the inclusion criteria. Positron Emission Computed Tomography (PET) images of patients who have undergone or plan to undergo surgery are analyzed; finally, appropriate statistical methods are used for analysis.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: July 2024
• Est. primary completion date: December 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

Meet the diagnostic criteria for epilepsy,

• No contraindications for fMRI examination.

• The patient had no other heart and lung diseases except epilepsy.

• Patients and their families were aware of this study and signed informed consent.

Exclusion Criteria:

• Patients with severe infection, cerebrovascular disease, malignant tumor and other systemic diseases that can affect the nervous system, and those with serious dysfunction of the heart, liver, kidney and other organs.

• Non-epileptic seizures such as syncope and hysteria.

• Pregnant or lactating women. Incomplete clinical data

Related Conditions & MeSH terms

• Epilepsy
• Epileptic Seizure
• Seizures

Intervention

Other:
• No intervention
No intervention

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Li Shuangshuang

References & Publications (1)

Kassinopoulos M, Harper RM, Guye M, Lemieux L, Diehl B. Altered Relationship Between Heart Rate Variability and fMRI-Based Functional Connectivity in People With Epilepsy. Front Neurol. 2021 Jun 10;12:671890. doi: 10.3389/fneur.2021.671890. eCollection 2021. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Seizure frequency		2022-2024
Primary	Seizure duration		2022-2024