Epileptic Seizures in Intensive Care Units

Epileptic Seizure Clinical Trial

Official title:

Epileptic Seizures in Intensive Care Units

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03860467
• Other study ID #: 2018-02361; me19Sutter
• Status: Completed
• Start date: December 1, 2019
• Est. completion date: April 30, 2022

Study information

• Verified date: June 2022
• Source: University Hospital, Basel, Switzerland
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This retrospective observational cohort study is to assess and analyze clinical, electroencephalographic, laboratory, comorbidity, and treatment characteristics of Intensive care unit (ICU)-patients with epileptic seizures and to subsequently compare their characteristics with ICU-patients with status epilepticus (SE).

Description:

The aim of this retrospective observational cohort study is to get further insight into adult patients with epileptic seizures in ICUs in an academic tertiary medical care center regarding frequency, clinical and electroencephalogram (EEG) characteristics, treatment, course and outcome. This data could help understanding the epidemiology (including risk factors, influence of EEG), and to guide management and improve outcomes of affected patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 200
• Est. completion date: April 30, 2022
• Est. primary completion date: April 30, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• admitted to the ICU at the University Hospital Basel

• suffered from one or more epileptic seizures (detected clinically and/or by EEG) during their ICU-stay

Exclusion Criteria:

• patients with epileptic seizures transforming into Status epilepticus (SE)

Related Conditions & MeSH terms

• Epilepsy
• Epileptic Seizure
• Seizures

Intervention

Other:
• collection of patient data
Patient data will be collected using the in-house digital patient record systems and the local digital electroencephalogram (EEG)-database

Locations

Country	Name	City	State
Switzerland	Clinic for Intensive Care Medicine, University Hospital Basel	Basel

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Basel, Switzerland

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Frequency of epileptic seizures	Frequency of all epileptic seizures in the ICU	between 01.01.2005 and 19.12.2018
Secondary	Number of epileptic seizures captured by EEG	Number of epileptic seizures captured by EEG without overt clinical seizure presentation in the ICU	between 01.01.2005 and 19.12.2018
Secondary	Number of epileptic seizures diagnosed on the basis of clinical symptoms alone	Number of epileptic seizures diagnosed on the basis of clinical symptoms alone in the ICU	between 01.01.2005 and 19.12.2018
Secondary	Length of epileptic seizure (time)	Duration of epileptic seizure	between 01.01.2005 and 19.12.2018
Secondary	Semiological feature of epileptic seizure (i.e. seizure types)	Semiological feature of epileptic seizure (i.e. seizure types) emerging in ICU-patients	between 01.01.2005 and 19.12.2018