Epilepsy Clinical Trial
Official title:
Idiopathic Generalized Epilepsy Syndromes: Clinical Features and Long-term Outcomes
The idiopathic generalized epilepsies (IGEs) have historically included the syndromes childhood absence epilepsy (CAE), juvenile absence epilepsy (JAE), juvenile myoclonic epilepsy (JME), and epilepsy with generalized tonic-clonic seizures alone (GTCA). Recognition of the IGEs is important for clinical care, as it informs diagnosis, prevents unnecessary investigation, allows optimal selection of anti-seizure medications (ASMs), and provides prognostic guidance. According to the new ILAE definition in 2022, the study aims to describe the clinical features, electroencephalographic, imaging findings and long-term prognosis.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | December 31, 2033 |
Est. primary completion date | December 31, 2026 |
Accepts healthy volunteers | |
Gender | All |
Age group | 4 Years to 40 Years |
Eligibility | Inclusion Criteria: - Patients are consecutively and prospectively enrolled from epilepsy center, with newly diagnosed epilepsy or established epilepsy. - Patients have a diagnosis of idiopathic generalized epilepsy (IGE), according to the 2022 diagnostic criteria. - Comprehensive clinical information is collected, and 24 hour video-electroencephalography is performed. - Sign the informed consent forms. Exclusion Criteria: - Other epilepsy syndromes are considered during follow-up, such as genetic generalized epilepsy. - Lost to follow-up |
Country | Name | City | State |
---|---|---|---|
China | 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China | Hangzhou | Zhejiang |
Lead Sponsor | Collaborator |
---|---|
Second Affiliated Hospital, School of Medicine, Zhejiang University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The proportion of drug-resistent epilepsy | We defined drug-resistant cases as those patients who have failed two or more trials of broad-spectrum ASMs or those otherwise indicated in IGE syndromes | through study completion, an average of 1 year | |
Primary | The proportion of seizure freedom | We defined seizure freedom according to the International League Against Epilepsy (ILAE) definition | through study completion, an average of 1 year | |
Secondary | The proportion of psychiatric comorbidity | The psychiatric comorbidities mainly include anxiety and depression, which are evaluated by Hamilton anxiety scale and Hamilton depression scale, respectively. | through study completion, an average of 1 year | |
Secondary | The proportion of psychosocial outcome | such as university entrance, marry | through study completion, an average of 1 year | |
Secondary | The proportion of seizure relapse after antiseizure medication withdrawn | Antiseizure medication withdrawn should be recommended by epilepsy experts | through study completion, an average of 1 year |
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