Neural Circuits for Action Perception

Epilepsy Clinical Trial

Official title:

Neural Circuits for Action Perception

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05507320
• Other study ID #: IRB_P0405065R
• Status: Recruiting
• Start date: September 1, 2021
• Est. completion date: September 1, 2025

Study information

• Verified date: August 2022
• Source: Boston Children's Hospital
• Contact: Gabriel Kreiman, PhD
• Phone: 6179192530
• Email: gabriel.kreiman[@]tch.harvard.edu
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Study the mechanisms underlying action recognition and execution

Description:

Subjects will participate in a task where they have to either

1. Perform a movement

2. Observe an actor performing a movement There are three types of actions including different kinematics and grip types The goal is to compare the neural circuits activated by action execution versus action observation.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 30
• Est. completion date: September 1, 2025
• Est. primary completion date: September 1, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 14 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients with pharmacologically intractable epilepsy

Exclusion Criteria:

• Any situation that may put the patient at risk

Related Conditions & MeSH terms

• Epilepsy

Intervention

Behavioral:
• Mechanisms of action perception and execution
Study the mechanisms of action perception and execution

Locations

Country	Name	City	State
United States	Boston Children's Hospital	Boston	Massachusetts

Sponsors (1)

Lead Sponsor	Collaborator
Boston Children's Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Selectivity for kinematics and movement type in neurophysiological responses	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.; We will assess selectivity for kinematics for each movement type	Through study completion, an average of 2 years.
Primary	Evoked responses by action execution	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.; We will quantify responses evoked by action execution	Through study completion, an average of 2 years.
Primary	Evoked responses by action observation	Measure intracranial field potentials (in microvolts) in the gamma frequency band through neurophysiological responses comparing neural responses during action perception versus execution.; We will quantify responses evoked by action observation	Through study completion, an average of 2 years.