Clinical Trials Logo

Clinical Trial Summary

Laser Induced Interstitial Thermal Therapy (LITT) is a "minimally invasive" procedure that uses the heat generated by a laser light (65°) to destroy brain lesions by coagulation leading to lesion necrosis under real-time MRI monitoring. The laser optical fiber is implanted into the lesion using stereotaxy. This technique, which can be performed under local anesthesia and on an outpatient basis, proved its efficacy and safety in the treatment of brain metastases for the first time in the world in 2006 (A. Carpentier et al, 2008, 2011). Since then, more than 5,000 patients have been treated in the USA, including for epileptogenic lesions (FDA device and CE cleared). Our goal is to evaluate LITT on lesions with drug-resistant epilepsy for which surgical resection is impossible. No therapeutic trial evaluating LITT in this indication has been performed to date. It is therefore necessary to study its feasibility and tolerance.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05198882
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Bertrand Mathon, MD
Phone 01 84 82 73 63
Status Recruiting
Phase Phase 1
Start date July 4, 2022
Completion date August 15, 2024

See also
  Status Clinical Trial Phase
Completed NCT04595513 - Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants Phase 1/Phase 2
Completed NCT02909387 - Adapting Project UPLIFT for Blacks in Georgia N/A
Completed NCT05552924 - Self Acupressure on Fatigue and Sleep Quality in Epilepsy Patients N/A
Not yet recruiting NCT05944692 - Epilepsy Seizure Detection With Innovative Tripolar EEG (tEEG)
Terminated NCT01668654 - Long-term, Open-label Safety Extension Study of Retigabine/Ezogabine in Pediatric Subjects (>= 12 Years Old) With POS or LGS Phase 3
Not yet recruiting NCT05068323 - Impact of Interictal Epileptiform Activity on Some Cognitive Domains in Newly Diagnosed Epileptic Patients N/A
Completed NCT03994718 - Creative Arts II Study N/A
Recruiting NCT04076449 - Quantitative Susceptibility Biomarker and Brain Structural Property for Cerebral Cavernous Malformation Related Epilepsy
Recruiting NCT05954182 - Cognitive Enhancement Intervention for Creating a Healthy L.I.F.E (Lifestyle Interventions for Epilepsy) N/A
Completed NCT00782249 - Trial Comparing Different Stimulation Paradigms in Patients Treated With Vagus Nerve Stimulation for Refractory Epilepsy N/A
Not yet recruiting NCT06019182 - MEHMO Natural History and Biomarkers
Completed NCT03683381 - App-based Intervention for Treating Insomnia Among Patients With Epilepsy N/A
Recruiting NCT05101161 - Neurofeedback Using Implanted Deep Brain Stimulation Electrodes N/A
Recruiting NCT05769933 - Bridging Gaps in the Neuroimaging Puzzle: New Ways to Image Brain Anatomy and Function in Health and Disease Using Electroencephalography and 7 Tesla Magnetic Resonance Imaging
Not yet recruiting NCT05865561 - Identification of Volatile Organic Compounds (VOCs) as Biopredictors of Epileptic Seizures
Not yet recruiting NCT06038929 - Effect of Vagal Nerve Stimulation on Gastric Motor Functions N/A
Not yet recruiting NCT05864612 - Tools for Anxiety and Depression Screening in Epilepsy N/A
Not yet recruiting NCT05871372 - Intracranial Investigation of Neural Circuity Underlying Human Mood N/A
Not yet recruiting NCT05296057 - Pilot to Evaluate VR-Therapy on People With Epilepsy and Related Anxiety N/A
Not yet recruiting NCT05559060 - Comorbidities of Epilepsy(Cognitive and Psychiatric Dysfunction)