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Clinical Trial Summary

Laser Induced Interstitial Thermal Therapy (LITT) is a "minimally invasive" procedure that uses the heat generated by a laser light (65°) to destroy brain lesions by coagulation leading to lesion necrosis under real-time MRI monitoring. The laser optical fiber is implanted into the lesion using stereotaxy. This technique, which can be performed under local anesthesia and on an outpatient basis, proved its efficacy and safety in the treatment of brain metastases for the first time in the world in 2006 (A. Carpentier et al, 2008, 2011). Since then, more than 5,000 patients have been treated in the USA, including for epileptogenic lesions (FDA device and CE cleared). Our goal is to evaluate LITT on lesions with drug-resistant epilepsy for which surgical resection is impossible. No therapeutic trial evaluating LITT in this indication has been performed to date. It is therefore necessary to study its feasibility and tolerance.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05198882
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Bertrand Mathon, MD
Phone 01 84 82 73 63
Status Recruiting
Phase Phase 1
Start date July 4, 2022
Completion date August 15, 2024

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