Epilepsy Clinical Trial
Official title:
Connectivity Alterations of Brain Network in LGG Patients After Levetiracetam Application at Short Term
This study aimed to analyze the connectivity alterations in brain networks of LGG patients with epilepsy who take levetiracetam at short-term preoperatively.
Glioma-related epilepsy (GRE) is a very common symptom in patients with diffuse gliomas.
Approximately 60% of patients with low-grade gliomas (LGGs) and 40-64% of patients with
high-grade gliomas presented with GRE at the onset. Although beneficial for the control of
GRE, the overall therapeutic effect was unsatisfied and over 20% of patients still suffered
from seizures.
GRE was found to be associated with brain network and functional connectivity. And it has
been reported that temporal lobe seizures could induce functional connectivity and decreased
network efficiency of brain networks. However, the alterations in functional networks induced
by GRE were still unclear. And LGG patients with GRE usually take levetiracetam (LEV)
preoperatively, which could effectively reduce abnormal spike activity and further cause
connectivity alterations. This makes it more complex to reveal the connectivity alterations
of brain networks in LGG patients with GRE.
This study aimed to collect the resting-state functional MRIs of 30 LGG patients who
presented with GRE at the onset. Through further applied graph theory analysis, investigators
tend to reveal the connectivity alterations of brain networks caused by levetiracetam. The
findings of this study will provide a theoretical basis for further study of connectivity
alterations of brain networks in patients with GRE.
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