Effect of Memantine on Cognitive Impairment in Patients With Epilepsy

Status Completed

Clinical Trial Summary

Evaluate the efficacy of memantine on improving the cognitive impairment in patient with epilepsy

Clinical Trial Description

Epilepsy is a complex disorder, which involves much more than seizures, encompassing a range of associated comorbid health conditions that can have significant health and quality-of-life implications. Of these comorbidities, cognitive impairment is one of the most common and distressing aspects of epilepsy.

Excito-toxicity, mediated by glutamate acting on N-methyl-D-aspartate (NMDA) receptors in the hippocampus, can cause memory dysfunction in epilepsy .

Memantine is a low-affinity voltage-dependent uncompetitive antagonist of the NMDA-type glutamate receptor . It also has antioxidant property and increases production of brain derived neurotropic factor (BDNF) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04417543
Study type	Interventional
Source	Assiut University
Contact
Status	Completed
Phase	Phase 1
Start date	October 1, 2018
Completion date	January 15, 2020

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