Serum and Urine Ghrelin in Adult Epileptic Patients

Epilepsy Clinical Trial

Official title:

Serum and Urine Ghrelin in Adult Epileptic Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03926273
• Other study ID #: ZU-IRB#5271\ 2-6-2018
• Status: Completed
• Start date: June 1, 2018
• Est. completion date: February 5, 2019

Study information

• Verified date: April 2019
• Source: Zagazig University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response.

Description:

Several neuropeptides have concerned with epilepsy pathogenesis, ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drugs (AED) response. Objective: to evaluate ghrelin effect in adult epileptic patients and in response to AED. Methods: This case control study included 40 adult epileptic patients and 40 healthy controls. Participants were subjected to history taking of seizure semiology, full general and neurological examination, electroencephalography and cranial CT or MRI. Fasting serum acylated ghrelin (AG) and unacylated ghrelin (UAG) and urine AG levels were estimated to all participants by enzyme - linked immunosorbent assay (ELIZA).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: February 5, 2019
• Est. primary completion date: January 30, 2019
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• All participants were included if their age more than or equal to 18 years. Body mass index < 30 kg/m2, total cholesterol < 200mg/dl, serum triglycerides < 200 mg/dl and random blood glucose level < 126 mg/dl.

Exclusion Criteria:

• Participants had acute or chronic metabolic disorders (liver, kidney, thyroid, endocrine or gastrointestinal disorders).

• Females with irregular menstrual cycle or on estrogen therapy (7).

• Participants with organic cerebral lesion that was detected on cranial computed tomography (CT) or cranial magnetic resonance imaging (MRI).

Related Conditions & MeSH terms

• Epilepsy

Locations

Country	Name	City	State
Egypt	Nageeb	Zagazig	El Sharkia

Sponsors (1)

Lead Sponsor	Collaborator
Zagazig University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Serum ghrelin in Adult Epileptic Patients	evaluation of the effect of Serum ghrelin in adult epileptic patients and in their response to anti- epileptic drugs	6 months
Primary	Urine ghrelin in Adult Epileptic Patients	evaluation of the effect of Urine ghrelin in adult epileptic patients and in their response to anti- epileptic drugs	6 months