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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03184597
Other study ID # 2017-hs-30
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date August 1, 2017
Est. completion date June 2021

Study information

Verified date August 2018
Source Second Affiliated Hospital of Guangzhou Medical University
Contact Wei-Ping Liao, M.D.,Ph.D.
Phone +86-20-34152625
Email wpliao@163.net
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Cutaneous adverse drug reactions (cADRs) include mild maculopapular exanthema (MPE) and severe cutaneous reactions such as hypersensitivity syndrome, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). cADRs are considered as a major public health issue because of their potentially life-threatening morbidity, especially severe cutaneous reactions. The incidence of SJS/TEN is estimated to vary from 1 in 1,000 to 10,000 drug exposures, and its mortality is as high as 35%. Antiepileptic drugs (AEDs), particularly those with aromatic ring structures such as carbamazepine (CBZ), oxcarbazepine (OXC), lamotrigine (LTG), phenobarbital (PB), and phenytoin (PHT), are among the most common causes of severe cutaneous reactions. The incidence of AED-induced SJS was estimated as 0.2% and all cases occurred in individuals receiving aromatic AEDs.

Previous studies have validated that the human leukocyte antigen (HLA) allele HLA-B*15:02 is strongly associated with CBZ-induced SJS/TEN in southern Han Chinese and populations in southeast Asia. Our recent studies indicated that HLA-A*24:02 is a common genetic risk factor for CBZ-, LTG-, and PHT-induced SJS/TEN. It is also associated with MPE. Additionally, another four alleles, including HLA-B*15:01, HLA-B*15:11, HLA-A*02:01,and HLA-DRB1*01:01, were showed to be potential risk factors for aromatic AEDs-induced SJS/TEN. In 2007, the US Food and Drug Administration issued the safety alert that recommended HLA-B*15:02 screening for people with Asian ancestry before starting CBZ, and avoidance of the drug if the test is positive. Subsequent studies from Taiwan, Hong Kong and Thailand demonstrated that HLA-B*15:02 screening before commencing CBZ can significantly reduce the incidence of CBZ-induced SJS/TEN. However, the overall incidence of AEDs-induced SJS/TEN remained unchanged in Hong Kong, as PHT-induced SJS/TEN increased when CBZ-SJS/TEN decreased. Moreover, no study focuses on the incidences of AEDs-induced cADRs with and without HLA screening before commencing aromatic AEDs. Therefore, we are planning to conduct a multicenter prospective study to examine the reduction of AEDs-induced cADRs after the HLA screening prior to the beginning of aromatic AEDs administration.


Description:

In this prospective study, 4000 or more patients from multicenters in southern China will be recruited. A HLA screening will be conducted before these patients start aromatic AEDs treatments. According to the HLA genotype, these patients will be divided into four groups that are three positive groups with different risk alleles and one negative group with no known risk allele. Aromatic AEDs were avoided or administrated with caution according to the risk level in the three positive groups, while they can be prescribed in the negative group. The effectiveness of HLA screening prior to the beginning of aromatic AEDs administration will be observed by the reduction of overall incidence of AEDs-induced cADRs.


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Study Design


Intervention

Diagnostic Test:
HLA screening before commencing aromatic AEDs
When the risk HLA alleles are tested positive for the patients, aromatic AEDs were avoided or administrated with caution according to the risk level.

Locations

Country Name City State
China The Second Affiliated Hospital of Guangzhou Medical Universty Guangzhou Guangdong

Sponsors (9)

Lead Sponsor Collaborator
Second Affiliated Hospital of Guangzhou Medical University First Affiliated Hospital of Jinan University, First Affiliated Hospital, Sun Yat-Sen University, First People's Hospital, Shunde China, Guangdong 999 Brain Hospital, Guangdong General Hospital, Guangzhou First People's Hospital, West China Hospital, Wuhan Women and Children's Medical Center

Country where clinical trial is conducted

China, 

References & Publications (7)

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Outcome

Type Measure Description Time frame Safety issue
Primary AEDs-induced cADRs incidence the incidence of AEDs-induced cADRs within the first 3 months of commencing an aromatic AED 3 months
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