Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery

Epilepsy Clinical Trial

Official title:

Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03102957
• Other study ID #: 38RC09.21
• Status: Completed
• Phase: N/A
• First received: March 22, 2017
• Last updated: April 5, 2017
• Start date: June 17, 2009
• Est. completion date: August 31, 2016

Study information

• Verified date: March 2017
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)

Description:

The purpose of this study is to explore the reorganization of neuroanatomic networks associated with language and memory in adult patients with temporal lobe epilepsy (ELT). By using functional MRI, patients will be examined before and after surgery. Cerebral plasticity, defined in terms of intrinsic variables such as the topography of the activated regions, will be explored according to some extrinsic factors such as the age at onset of crises (before or after 5-6 years), whether or not Hippocampal sclerosis, hemispheric predominance of language (left or right).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: August 31, 2016
• Est. primary completion date: August 31, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• epileptic patients

• medical exam before inclusion

• social security affiliation

• Pharmaco-resistant epilepsy

Exclusion Criteria:

• MRI contraindication

• pregnant women

• breastfeeding mothers

• person under tutorship

Related Conditions & MeSH terms

• Epilepsy

Intervention

Other:
• functional MRI

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Grenoble	Laboratoire de Psychologie et Neurocognition (LPNC)

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	neuronal reorganization exploration in language and memory area thanks to functionnal MRI	fMRI exam before and after resection surgery of epileptogenic area: assess (plasticity) of neuroanatomic networks associated with language and memory - examined before and after surgery	one hour for each exam