Epilepsy Clinical Trial
Official title:
Definition of Links Between Non-invasives Methods and Intracerebral EEG With Simultaneous Recordings.
Presurgical evaluation of epileptic patients require a precise mapping of cerebral regions
implied in epileptic discharges and in normal function.
The current practice in most cases is to implant intracerebral electrodes in order to
localize these regions in a reliable manner. However, non-invasive methods have been
developed in order to record brain activity with no risk for the patient.
Still, it is necessary to validate and improve the signal processing methods and the
underlying models these methods in order to optimize their use in clinical practice. To do
so, it is necessary to record simultaneously electroencephalogram (EEG) and
magnetoencephalogram (MEG) and stereo encephalogram SEEG (intracerebral). Such simultaneous
recordings will permit to confront the exact same activity recorded non-invasively at the
surface of the head, and represented on the brain thanks to the model and directly within the
brain.
The objective is to define the conditions under which one can represent faithfully the
activity measured intracerebrally from the surface measurements.
It will be record simultaneously MEG, scalp EEG and intracerebral EEG on a series of 60
patients. It will be record resting state signals, as well as stimulation protocols. The
interictal epileptic discharges will be marked on the different modalities, and evoked
potentials/fields computed in response to protocols. Sensitivity of recordings to activity
visible on depth recordings will be evaluated as a function of localization of brain
generators. Advanced signal processing methods will be used such as source localization and
independent component analysis, in order to increase sensitivity of measures.
n/a
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