Recording High Frequency Oscillations in Patients With Tumors and Epilepsy

Epilepsy Clinical Trial

— HFO  

Official title:

Recording High Frequency Oscillations in Patients With Tumors and Epilepsy.

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT02320136
• Other study ID #: HFO
• Status: Enrolling by invitation
• Start date: June 2014
• Est. completion date: December 2025

Study information

• Verified date: November 2023
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation.

The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 120
• Est. completion date: December 2025
• Est. primary completion date: December 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 99 Years

Eligibility

Inclusion Criteria:

• Patients intend to be treated at the Klinik für Neurochirurgie

• Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery. (2)Patients where a tumor is planned to be resected that has caused preoperative seizures. (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.

• Male and Female subjects 18 years to 99 years of age

• Written informed consent after participants' information

Exclusion Criteria:

• contraindications on ethical grounds

• known or suspected non-compliance, drug or alcohol abuse,

• enrolment into a clinical trial within last 4 weeks

Related Conditions & MeSH terms

• Epilepsy
• Tumor

Intervention

Behavioral:
• cognitive testing
patients perform simple tasks like watching a video or memorizing items

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	HFO (high-frequency oscillations) occurrence		1 week