Clobazam Use in Epilepsia Partialis Continua - Pilot Study

Epilepsy Clinical Trial

Official title: A Phase III, Randomized, Open Label, Single Center, Study on the Effects of Treatment of Epilepsia Partialis Continua With Clobazam Compared to Treatment With or in Addition to Lorazepam and/or Clonazepam

Status Terminated

Clinical Trial Summary

The purpose of this study is to evaluate whether clobazam, brand name Onf®, is more effective as an adjunctive or monotherapy in terminating Epilepsia Partialis Continua (EPC) than either lorazepam and/or clonazepam.

Clinical Trial Description

First approved in the United States in 2011 for use in treating Lennox-Gastaut syndrome, clobazam is the only 1, 5-benzodiazepine that is currently approved for clinical use in the United States. In previous clinical trials clobazam has been shown to have a greater efficacy and produce fewer side effects in individuals when it's adverse event profile is compared to the traditional 1,4-benzodiazepines such as diazepam, lorazepam, and clonazepam. As a benzodiazepine, clobazam has been found to have anticonvulsant properties, and structural differences as a 1,5-benzodiazepines that appear to have a broader spectrum of anticonvulsant activity than those found in 1,4-benzodiazepines. In previous reports, clobazam has been seen to be effective in ether terminating or reducing both EPC in particular and partial status epilepticus. ;

Related Conditions & MeSH terms

• Epilepsia Partialis Continua
• Epilepsy
• Kojewnikov's Epilepsy

• NCT number: NCT02134366
• Study type: Interventional
• Source: The Cooper Health System
• Status: Terminated
• Phase: Phase 3
• Start date: July 2014
• Completion date: July 2017