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NCT01210781 Clinical Trial

Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation

Epilepsy Clinical Trial

Official title:
Target Planning for Placement of DBS-electrodes and Follow-up of the Clinical Efficacy of Stimulation

Clinical Trial Details — Status: Enrolling by invitation

Administrative data
NCT number NCT01210781
Other study ID # DBS
Secondary ID
Status Enrolling by invitation
Phase
First received
Last updated
Start date September 2009
Est. completion date December 2025

Study information
Verified date November 2023
Source University of Zurich
Contact n/a
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN). Nevertheless, there is no agreement on the mechanisms how DBS leads to clinical improvement. The project aims to describe the variability of target coordinates in the patient group and to relate it to clinical outcome as documented in standardized questionaires. - Trial with surgical intervention

Description:

Deep brain stimulation (DBS) has been established as therapy for severe forms of Parkinson's disease and other indications. A common target for stimulation is the subthalamic nucleus (STN). Nevertheless, there is no agreement on the mechanisms how DBS leads to clinical improvement. The project aims to describe the variability of target coordinates in the patient group and to relate it to clinical outcome as documented in standardized questionaires.

Recruitment information / eligibility
Status Enrolling by invitation
Enrollment 500
Est. completion date December 2025
Est. primary completion date December 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years to 90 Years
Eligibility Inclusion criteria: - Patients fullfill all criteria for implantation of deep brain stimulation (DBS) electrodes - Patients are able to give informed written consent Exclusion criteria: - Patients do not their give informed written consent

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• deep brain stimulation (DBS)
deep brain stimulation (DBS) is in itself not part of this study but a clinical indication. The study aims at documenting DBS parameters and outcome

Locations
Country Name City State
Switzerland University Hospital Zurich, Neurosurgery Zurich ZH

Sponsors (1)
Lead Sponsor Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary neurological outcome UPDRS 5 years
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