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Epilepsy, Tonic-Clonic clinical trials

View clinical trials related to Epilepsy, Tonic-Clonic.

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NCT ID: NCT05637086 Recruiting - Epilepsy Clinical Trials

Clinical Study Evaluating Safety of Pentoxifylline in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy

Start date: December 20, 2022
Phase: Phase 2
Study type: Interventional

Epilepsy is a chronic neurological disorder affecting millions of people all over the world. Epileptic seizures are caused by abnormal synchronized electrical neuronal discharges that could be either focal or widespread. Pathogenesis of epilepsy involves multiple processes including genetics, oxidative stress, ion channels, neuroinflammation, and cellular damage through autophagy and apoptosis. Neuroinflammation is considered one of the most important factors contributing critically to epileptogenesis.

NCT ID: NCT04770337 Recruiting - Epilepsy Clinical Trials

Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy

Start date: October 25, 2021
Phase: N/A
Study type: Interventional

This is a multiple site, randomized, double blinded parallel-group controlled study. The purpose of this study is to evaluate efficacy, safety, and tolerability of repeated, daily sessions with the STARSTIM device, which delivers transcranial cathodal direct current stimulation (tDCS). Subjects will be treated with STARTSTIM or sham device for 10 sessions over a 2-week period. The subjects will be followed for an additional 10 weeks post treatment. Quality of Life questionnaires and adverse events will be collected and evaluated.

NCT ID: NCT04282681 Withdrawn - Clinical trials for Epilepsy, Tonic-Clonic

XLTCS - Accelerometer Data Collection in an Epilepsy Monitoring Unit (EMU)

XLTCS
Start date: March 16, 2020
Phase:
Study type: Observational

The primary objective of this study is to collect accelerometer data from subjects monitored in an EMU with concurrent video EEG.

NCT ID: NCT03831802 Terminated - Clinical trials for Epilepsy, Tonic-Clonic

Embrace and Quality of Life

EMBQL
Start date: October 10, 2018
Phase: N/A
Study type: Interventional

A prospective, open, randomized, pilot clinical trial which aims the assessment of quality of life (QOL) in epilepsy outpatients equipped with a wrist-worn biosensor that provides measures of electrodermal activity and accelerometry. These measures are used to automatically detect epileptic seizures that are transmitted to a mobile phone-based system for alerts and recording.

NCT ID: NCT03446664 Completed - Epilepsies, Partial Clinical Trials

Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study

Microburst
Start date: February 27, 2018
Phase: N/A
Study type: Interventional

Evaluate the initial safety and effectiveness of Microburst VNS stimulation in subjects with refractory epilepsy.

NCT ID: NCT01439438 Completed - Clinical trials for Epilepsy, Tonic-Clonic

Topiramate Bioequivalence Study Brazil - Fast

Start date: July 22, 2011
Phase: Phase 1
Study type: Interventional

This study is prospective, open-label, randomized, crossover, single dose, with 02 treatments, 02 sequences and 02 periods. The volunteers received, in each period, the reference or the test formulation, according to the randomization list, under fasting conditions, in order to evaluate if the reference and test formulations are bioequivalent.

NCT ID: NCT00231556 Completed - Epilepsy Clinical Trials

A Study on Safety and Efficacy of Two Doses of Topiramate as Monotherapy in the Treatment of Newly Diagnosed or Recurrent Epilepsy

Start date: July 1999
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the safety and effectiveness of two doses of topiramate as monotherapy in the treatment of pediatric and adult patients with newly diagnosed or recurrent epilepsy.

NCT ID: NCT00150813 Completed - Clinical trials for Epilepsy, Tonic-clonic

Monotherapy With Levetiracetam in Patients Suffering From Epilepsy.

Start date: August 10, 2005
Phase: Phase 3
Study type: Interventional

An open-label follow-up trial assessing the long term safety of levetiracetam as per adverse events reporting.

NCT ID: NCT00150787 Completed - Clinical trials for Epilepsy, Tonic-clonic

Monotherapy With Levetiracetam or Carbamazepine in Patients Suffering From Epilepsy.

Start date: July 2003
Phase: Phase 3
Study type: Interventional

A double-blind follow-up trial assessing the long term safety of Levetiracetam as per adverse events reporting, physical and neurological examination and vital signs

NCT ID: NCT00104416 Completed - Epilepsy Clinical Trials

Study Evaluating LAMICTAL Extended-Release Therapy Added To Current Seizure Treatments In Patients With Primary Generalized Tonic-Clonic Seizures (PGTC) Seizures

Start date: December 2004
Phase: Phase 3
Study type: Interventional

This study is being conducted to compare the efficacy and safety of LAMICTAL (lamotrigine) extended-release with placebo in the treatment of Primary Generalized Tonic-Clonic (PGTC) seizures. LAMICTAL extended-release is an investigational drug. Placebo tablets look like LAMICTAL extended-release tablets but do not contain active medication. In this study, LAMICTAL extended-release or placebo tablets will be added to current seizure treatments.