| Eligibility |
Inclusion Criteria:
1. Subjects greater than 18 years of age
2. Subjects with brain tumour-related epilepsy
3. Subjects with a history of uncontrolled seizures (at least three focal-onset seizure
per month over the last 28 days)
4. Subjects currently being treated with at least one appropriate AED
5. Subjects who have had a brain MRI performed in the last three months preceding the
signing of informed consent
6. Subjects with primary brain tumour with an IDH1 mutation (to be determined during the
screening period)
7. Subjects with satisfactory hematologic, renal and liver function, as assessed by the
Principal Investigator
8. Subject with a Karnofsky performance scale index (KPD) of > 70%
9. An expected survival time > 6 months
10. A female subject is eligible to participate if she is not pregnant by serum pregnancy
test, not breastfeeding, and at least 1 of the following conditions applies:
1. Not of childbearing potential, defined as surgically sterile (documented
hysterectomy, bilateral salpingectomy or bilateral oophorectomy) or
postmenopausal (no menses for 12 months without an alternative medical cause. A
high follicle stimulating hormone (FSH) level in the postmenopausal range may be
used to confirm a postmenopausal state in women not using hormonal contraception
or hormonal replacement therapy; however, in the absence of 12 months of
amenorrhea, a single FSH measurement is insufficient)
2. Of childbearing potential and agrees to use a highly effective method of
contraception consistently during the 4-week dose escalation, 16-week treatment,
and 4-week washout periods; and for at least 30 days after the last dose of study
treatment
11. A male patient with a female partner of childbearing potential is eligible to
participate if he agrees to use acceptable contraception during 4-week dose
escalation, 16-week treatment, and 4-week washout periods; and for at least 30 days
after the last dose of study treatment and refrains from donating sperm during this
period
12. Willing to participate in the study and willing to provide written signed informed
consent.
Exclusion Criteria:
1. Urgent need for surgical intervention
2. Alanine aminotransferase or aspartate aminotransferase > 10 times the upper reference
limit at the screening visit
3. Estimated glomerular filtration rate < 60 mL/min (calculated using the using the
Chronic Kidney Disease Epidemiology Collaboration Creatinine Equation) at the
screening visit
4. Any haematological National Cancer Institute Common Terminology Criteria for Adverse
Events (NCI CTCAE) v5.0 Grade = 3 (with the exception of alopecia) at the screening
visit
5. Factors that significantly affect oral drug absorption, such as inability to swallow,
chronic diarrhoea, short bowel syndrome, and/or intestinal obstruction
6. Hypertension that cannot be reduced to normal range with antihypertensive medication
(systolic blood pressure > 140 mmHg, diastolic blood pressure > 90 mmHg)
7. Concurrent active cancer that requires non-surgical treatment (e.g., chemotherapy,
radiotherapy, adjuvant therapy)
8. History of severe cardiovascular disease: myocardial ischemia or myocardial infarction
of Grade 2 or above, poorly controlled arrhythmia (including QTc interval =450 ms for
men, =470 ms for women); according to New York Heart Association standards, Grade 3 or
4 cardiac insufficiency, or colour doppler ultrasound examination of the left
ventricular ejection fraction < 50% as assessed at the screening visit
9. In the Investigators opinion, the subject's involvement may affect the progress of the
clinical study and/or the determination of the research results, and/or considers them
unsuitable for inclusion
10. Previously suffered severe cardiovascular disease: myocardial ischemia or myocardial
infarction of Grade 2 or above, poorly controlled arrhythmia (including QTc interval
=450 ms for men, =470 ms for women); according to New York Heart Association
standards, Grade 3 or 4 cardiac insufficiency, or color doppler ultrasound examination
of the left ventricular ejection fraction < 50%.
11. Investigator judges that may affect the progress of the clinical study and/or the
determination of the research results, and/or considers them unsuitable for inclusion.
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