Clinical Trials Logo
  1. Home
  2. Epilepsy; Seizure
  3. NCT04737174

ES-481 for Uncontrolled Glioma-Associated Epilepsy and Assessment for Potential Anti-Tumorigenic Effect in Patients With Isocitrate Dehydrogenase 1 (IDH1) Mutant Tumors

Epilepsy; Seizure Clinical Trial

Official title:
Adjunctive ES-481 for Uncontrolled Glioma-Associated Epilepsy and Assessment for Potential Anti-Tumorigenic Effect in Patients With Isocitrate Dehydrogenase 1 (IDH1) Mutant Tumors

Clinical Trial Summary

Phase 2A single-arm exploratory clinical study in up to 12 adult subjects aged 18 and older with primary glioma, IDH1 mutation, and uncontrolled focal-onset seizure activity to determine the potential efficacy, safety and pharmacokinetics of ES-481 as adjunctive therapy in glioma-associated epilepsy and to assess for potential anti-tumorigenic effects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04737174
Study type Interventional
Source ES Therapeutics Australia Pty Ltd
Contact
Status Withdrawn
Phase Phase 2
Start date March 25, 2021
Completion date April 2022
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT03548779 - North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 N/A
Completed NCT05605301 - Pharmacokinetics Study of Oral 2-Deoxy-D-Glucose (2DG) in Subjects With a Confirmed Diagnosis of Epilepsy Phase 2
Completed NCT05257811 - Earbud EEG Feasibility Study
Recruiting NCT05066880 - Yoga and Aerobic Exercise in Epilepsy N/A
Recruiting NCT06278428 - Genotype, Phenotype, and Disease Progression of Developmental Epileptic Encephalopathy With Onset Before 2 Years of Age
Terminated NCT04639310 - XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy Phase 3
Not yet recruiting NCT06275685 - Forecasting Seizures Using Intelligent Wearable Technology for Health Tracking N/A
Completed NCT04822662 - The Individual and Family Self Management Theory Based Epilepsy Education Program's Effectiveness N/A
Recruiting NCT04759196 - Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas Phase 4
Completed NCT04171934 - Clinical Validation of a Video-based Epilepsy Examination Service
Recruiting NCT04569708 - Sleep Spindles and Memory in Rolandic Epilepsy N/A
Completed NCT04311151 - Impact of Self-visualization of Epileptic Seizures on Patients' Perception of the Disease and Risk Behavior N/A
Not yet recruiting NCT05635396 - Seizures Detection in Real Life Setting N/A
Completed NCT05675254 - The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
Terminated NCT04912856 - An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE Phase 3
Recruiting NCT04221282 - ZEBinix® Retention Rate in Epilepsy in Elderly Patients