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Epilepsy, Complex Partial clinical trials

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NCT ID: NCT04573569 Completed - Clinical trials for Epilepsy, Complex Partial

Neural Correlates of Cognition and Mood

Start date: March 28, 2018
Phase:
Study type: Observational

The overall objective of this study is to determine the neural correlates of cognition and mood. This study represents the first preliminary study to begin investigating cognitive and emotional states in patients who have undergone implantation of invasive electrodes for the purpose of seizure localization. In the post-implantation paradigm where patients remain under close supervision with intracranial instrumentation for recording, this study aims to create the platform and preliminary data to inform a larger study for calibrated examination of neural correlates of cognition and mood. As such, this study has the following specific aims: Aim 1: Establish a portable platform for the assessment of cognitive, behavioral, and emotional tasks with time synchronization to ECoG/SEEG recording platform Aim 2: Quantify the variance in clinical assessments of mood and cognitive function in patients undergoing phase II epilepsy monitoring Aim 3: Assess the relationship between validated surveys/tasks and electrophysiology

NCT ID: NCT03156439 Completed - Clinical trials for Epilepsy, Complex Partial

Bioavailability, Safety, and Tolerability of BIS-001 ER

Start date: May 22, 2017
Phase: Phase 1
Study type: Interventional

This study investigates the safety, tolerability, and pharmacokinetics of BIS-001 ER in healthy volunteers. Subjects will be dosed twice daily, with a dose escalation occurring every 2-3 days until a maximum dose of 5mg per day is reached.

NCT ID: NCT01002820 Completed - Clinical trials for Epilepsy, Complex Partial

A Treatment Use Protocol for Subjects Continuing on From the Open-label Extension 0601

0602
Start date: October 2009
Phase: Phase 2
Study type: Interventional

This study is designed to provide ganaxolone to those patients deriving significant benefit from current treatment in protocol 1042-0601.

NCT ID: NCT00991757 Completed - Epilepsy Clinical Trials

An Open-Label Extension Study to Evaluate the Safety and Tolerability of RWJ 333369 as Adjunctive Therapy in Patients 16 Years and Older With Partial Onset Seizures.

Start date: February 2007
Phase: Phase 3
Study type: Interventional

The purpose of this open-label extension study is to demonstrate that RWJ-333369 is safe as long-term add-on treatment of partial onset seizures.

NCT ID: NCT00744731 Completed - Clinical trials for Epilepsy, Complex Partial

An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures

Start date: January 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to obtain long-term safety and tolerability information on carisbamate as add-on therapy for the treatment of partial onset seizures in patients with epilepsy. Seizure counts will be obtained to measure the rate of seizures for each patient during the study.

NCT ID: NCT00740623 Completed - Clinical trials for Epilepsy, Complex Partial

A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures.

Start date: January 2009
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the effectiveness, safety, and tolerability of carisbamate as add-on therapy for the treatment of partial onset seizures in patients with epilepsy.

NCT ID: NCT00537940 Completed - Epilepsy Clinical Trials

Comparative Study Of Pregabalin And Gabapentin As Adjunctive Therapy In Subjects With Partial Seizures

Start date: February 2008
Phase: Phase 4
Study type: Interventional

To compare the efficacy of pregabalin and gabapentin, as adjunctive therapy in subjects with partial seizures.

NCT ID: NCT00433667 Completed - Epilepsy Clinical Trials

A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.

Start date: November 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate that RWJ-333369 is safe and effective as add-on treatment of partial onset seizures.

NCT ID: NCT00425282 Completed - Epilepsy Clinical Trials

A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.

Start date: November 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to demonstrate that RWJ-333369 is safe and effective as add-on treatment of partial onset seizures.

NCT ID: NCT00319501 Completed - Epilepsy Clinical Trials

Efficacy and Safety of Vanquix for the Management of Selected, Refractory, Patients With Epilepsy Who Require Intermittent Caregiver Medical Intervention to Control Episodes of Acute Repetitive Seizures.

Start date: January 2006
Phase: Phase 3
Study type: Interventional

To evaluate the efficacy and safety of Vanquix for the management of selected, refractory, patients with epilepsy who require intermittent medical intervention provided by caregivers who are not health care professionals, and who are not under the direct supervision of a healthcare professional at the time of administration to control episodes of acute repetitive seizures (ARS).