Epilepsies Clinical Trial
Official title:
Structural and Functional Connectivity in Partial Epilepsies Studied With MRI and MEG
Surgery may be an effective therapy for refractory focal epilepsies with a clear delineated
focus but surgical benefits are less clear for patients with a poorly defined focus such as
non lesional refractory partial epilepsies.
SEEG is considered the criterion standard to localize the epileptogenic zone (EZ) but the
procedure is risky with a limited spatial sampling. The development of non-invasive
neuroimaging alternatives is thus an important goal to improve EZ delineation and optimize
SEEG procedures.
The main hypothesis of this research project is the existence of a network organization
specific for each patient which allows the generation and propagation of epileptic
activities. The investigators wish to explore this network using diffusion tensor MRI to
study structural connectivity and MEG/FMRI to study functional connectivity. The
investigators will apply tools from the theories of complex networks and dynamical systems
to characterize the network organization of epileptic process.
The investigators aimed to identify and localize differences in connectivity parameters
between individual patients and a control group of healthy volunteers.
n/a
Observational Model: Case Control, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00367432 -
A Long Term Follow up Administration Study of L059 (Levetiracetam) in Epilepsy Patients With Partial Onset Seizures
|
Phase 3 |