Epidural Anesthesia Clinical Trial
Official title:
The Effect of Oral Pregabalin on Epidural-induced Shivering and Epidural Characteristics in Gynecological Surgeries, a Prospective Randomized Double-blind Study
Verified date | January 2019 |
Source | Beni-Suef University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
- Background: The previous reports tried to reduce shivering and improve neuroaxial
anesthesia characteristics by the systemic use of different drugs. This study was
directed to evaluate the effect of pregabalin premedication on both shivering and
epidural outcome data following single shot loading.
- Patients and Methods: Eighty patients, ASA grade I and II, undergoing surgeries under
epidural anesthesia were studied. The patients were divided into two groups: Pregabalin
group and Control group in which the patients received 150 mg of pregabalin and placebo
capsules respectively sixty minutes prior to surgery. Following epidural loading, the
onset and degree of shivering were compared between the two groups. Also, the epidural
outcome including onset, level and duration were traced and compared. The perioperative
hemodynamics, sedation scores, patient satisfaction and side effects were followed up
and registered.
Status | Completed |
Enrollment | 77 |
Est. completion date | November 15, 2018 |
Est. primary completion date | November 15, 2018 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: - adults female patients (20 - 60 years old) - with an American society of Anesthegiologists physical status (ASA) I-II - undergoing gynecological surgery Exclusion Criteria: - ASA class was more than II, - anticipated difficult epidural insertion - any contraindication to epidural anesthesia, if any patient developed wet or bloody tab, or the patients were under psychotropic or antiepileptic therapy. |
Country | Name | City | State |
---|---|---|---|
Egypt | Beni suef university hospiital | Bani Suwayf |
Lead Sponsor | Collaborator |
---|---|
Beni-Suef University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | - Shivering | incidence of positive shivering , | starting from epiural injection, up to 60 minutes after epidural anesthesia | |
Primary | Shivering | incidence of maximum shivering | starting from epiural injection, up to 60 minutes after epidural anesthesia | |
Secondary | - Epidural characteristics | onset of the block (the time from epidural loading until feeling of numbness in the lower extremities) | from epidural injection till numbing sensation (approximately 10 minutes) | |
Secondary | Epidural characteristics | duration of the block (the time from the onset till starting feeling of pain at the surgical site) | from epidural onset to starting feeling pain (approximately 90 minutes) |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT03317626 -
Gravity Flow Technique to Validate Proper Location of Epidural Needle Tip
|
N/A | |
Completed |
NCT05327088 -
Epidural Dexmedetomidine vs Nalbuphine for Labor Analgesia
|
Phase 2 | |
Completed |
NCT05557383 -
Effect of Using Peanut Ball on the Length of Labor for Women Laboring With an Epidural
|
N/A | |
Completed |
NCT04721054 -
Thoracic Epidural Versus General Anesthesia for Laparoscopic Cholecystectomy
|
N/A | |
Completed |
NCT03341819 -
Comparative Study Between Retained and Non-retained Urinary Catheter in Total Knee Arthorplasty With Epidural Anesthesia
|
N/A | |
Completed |
NCT01661907 -
Anesthesia-analgesia Methods and Postoperative Delirium
|
N/A | |
Completed |
NCT01559285 -
Effects of Epidurally Administered Ropivacaine Concentration on the Hemodynamic Parameters
|
Phase 4 | |
Completed |
NCT03012945 -
Epidural Anesthesia-analgesia and Long-term Outcome
|
N/A | |
Completed |
NCT04373174 -
The Effect of Regional Anesthesia Techniques on Brain Tissue Oxygenation in Thoracic Surgery
|
N/A | |
Completed |
NCT05344079 -
Comparison of the Effects of Epidural Analgesia and Local Infiltrative Analgesia Methods on Pain Control
|
N/A | |
Recruiting |
NCT03443466 -
Efficacy and Safety of Electric Stimulation-guided Epidural Anesthesia for Cesarean Section
|
N/A | |
Completed |
NCT03100968 -
Utility of Ultrasound in Identification of Midline and Placement of Epidural in Severely Obese Parturients
|
N/A | |
Recruiting |
NCT02537665 -
Heating Precondition of Epidural Catheter Decrease the Incidence of Injury to Blood Vessel During Epidural Catheter Placement
|
N/A | |
Completed |
NCT06316921 -
Epidural PCA on Pain Relief After L-spine Surgery
|
||
Completed |
NCT00156338 -
Effect of Intraoperative Fluid Management on Morbidity
|
N/A | |
Withdrawn |
NCT00811304 -
Real-time Ultrasound Guided Labor Epidural Placement
|
N/A | |
Completed |
NCT00552864 -
Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia
|
Phase 4 | |
Active, not recruiting |
NCT03195309 -
A Comparison of Different Concentration Ropivacaine for Patient-controlled Epidural Analgesia
|
Phase 1/Phase 2 | |
Completed |
NCT04222192 -
Different Type Ultrasound Guided Epidural Block Methods
|
N/A | |
Completed |
NCT03335826 -
Epidural Anesthesia and Long-term Outcomes in Elderly Patients After Surgery
|
N/A |